{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:54:18Z","timestamp":1787630058318,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dual kidney transplantation (DKT), an uncommonly performed procedure, provides a unique opportunity to transplant nonstandard kidneys that might otherwise not be utilized. We compared perioperative and five\u2010year posttransplant outcomes between DKT, and single kidney transplants (SKT) performed at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed all adult deceased donor kidney\u2010alone transplant recipients at our center between 2001 and 2020. Recipients of pediatric\n                      <jats:italic>en bloc<\/jats:italic>\n                      kidney transplants were excluded. Perioperative outcomes of interest included delayed graft function (DGF), posttransplant length of stay (LOS), rehospitalization, and reoperation. Five\u2010year outcomes included biopsy\u2010proven acute rejection (AR), death\u2010censored graft failure (DCGF), uncensored graft failure (UCGF), and death with functioning graft (DWFG).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 100 DKT and 3125 SKT recipients were included. DKT recipients were older (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), more often male (68%), and more often underwent early steroid withdrawal (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04). In comparison to SKT, after adjustment for multiple variables, DKT was not independently associated with DGF (aOR: 1.25; 95% CI 0.76\u20132.08); prolonged LOS (linear coefficient 0.42; \u22120.9\u20131.7); reoperation (aOR: 0.73; 95% CI: 0.21\u20132.51) or rehospitalization (aOR 0.98; 95% CI: 0.55\u20131.74). However, within five years, DKT had a lower adjusted incidence rate ratio (aIRR) for AR (aIRR: 0.28; CI 0.12\u20130.64); DCGF (aIRR: 0.30; 95% CI 0.13\u20130.68), and UCGF (aIRR: 0.53; 95% CI: 0.33\u20130.86), without statistically significant differences in DWFG (aIRR: 0.83; 95% CI: 0.46\u20131.53).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In selected recipients, DKT offered superior medium\u2010term outcomes compared to SKT without compromising perioperative outcomes. DKT can mitigate concerns associated with medically complex donor kidneys, increase organ utilization, and increase access to transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70481","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:12:39Z","timestamp":1770880359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Kidney Transplantation Offers Prolonged Graft Survival"],"prefix":"10.1111","volume":"40","author":[{"given":"Ekaterina","family":"Fedorova","sequence":"first","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Nehring","family":"Firmino","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison School of Medicine and Public 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