{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:55:55Z","timestamp":1781715355787,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Liver transplantation (LT) is the standard treatment for Wilson disease (WD) with end\u2010stage liver failure, but its use for severe neurological symptoms remains controversial due to reports of paradoxical post\u2010transplant deterioration. This study examines the risk and predictors of neuropsychiatric symptoms after LT for WD compared to other liver diseases. We conducted a retrospective cohort study using the TriNetX US Collaborative Network. WD patients who underwent LT were matched 1:1 with non\u2010WD LT recipients using propensity score matching (PSM) based on demographics, comorbidities, laboratory values, and immunosuppressant use. Cox proportional hazards models assessed the 5\u2010year risk of composite neuropsychiatric symptoms (defined as the occurrence of any seizure disorder, movement disorder, mood or anxiety disorder, insomnia, cognitive deficit, neuromuscular disorder, psychotic disorder, or delirium) as well as specific symptom components and identified predictors in the LT\/WD group. Among 484 LT\/WD and 88\u00a0486 LT\/non\u2010WD patients (475 per group post\u2010PSM), WD patients had higher rates of the composite and several specific neuropsychiatric symptoms, including tremors, anxiety, insomnia, mood disorders, and myoneural junction disease. After PSM, the composite neuropsychiatric symptoms remained significantly elevated in LT\/WD patients (HR 1.3,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007). Predictors in LT\/WD included Asian race (HR 2.0,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04), diabetes (HR 1.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), smoking (HR 1.8,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03), and cyclosporine\u2010based immunosuppression compared with non\u2010cyclosporine regimens (HR 2.5,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007). Patients with WD undergoing LT face a higher long\u2010term risk of neuropsychiatric symptoms compared with non\u2010WD recipients. Identification of high\u2010risk subgroups and potentially modifiable factors, including immunosuppressive regimen selection, may inform post\u2010transplant surveillance and management strategies.\n                  <\/jats:p>","DOI":"10.1111\/ctr.70491","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:56:15Z","timestamp":1772996175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuropsychiatric Symptoms After Liver Transplant for Wilson's Disease: A US\u2010Based Multicenter Retrospective Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-2799","authenticated-orcid":false,"given":"Mohammad","family":"Aldiabat","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T H Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Medicine Washington University in St Louis  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adam","sequence":"additional","affiliation":[{"name":"Department Of Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Sallam","sequence":"additional","affiliation":[{"name":"Department Of Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Y.","family":"Madi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqr","family":"Alsakarneh","sequence":"additional","affiliation":[{"name":"Department Of Medicine University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Basil","family":"Nasir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing\u2010Kin","family":"Syn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University  St Louis Missouri USA"},{"name":"Department of Physiology Faculty of Medicine and Nursing University of Basque Country UPV\/EHU  Vizcaya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70190-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30911"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-344"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.11.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.08.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.1.12"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125318759461"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22261"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.06.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.71079\/ASIDE.IM.03222516"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114855"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-022-01872-w"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.mesot2014.P176"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"44","article-title":"Tacrolimus\u2010Induced 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