{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:59:07Z","timestamp":1781816347252,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although advanced age is no longer a contraindication for renal transplantation, real\u2010world data on elderly transplant recipients remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, prospective study enrolled de novo kidney transplant recipients aged 60 years or older receiving once\u2010daily tacrolimus immunosuppression, following recovery of renal function and referral to the transplant clinic. The primary objective was to describe clinical characteristics and post\u2010transplant outcomes over a 12\u2010month follow\u2010up. Secondary objectives included assessing changes in quality of life and the relationship between biopsy\u2010proven acute rejection (BPAR) and tacrolimus levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 280 evaluable patients, 239 completed the 12\u2010month follow\u2010up (mean recipient age: 69.8 years; mean donor age: 69.1 years) and 41 (14.6%) terminated due to graft loss (13, 31.7%), tacrolimus termination (12, 29.3%), death (10, 24.4%), loss to follow\u2010up (3, 7.3%), other (2, 4.9%), and temporary tacrolimus interruption (1, 2.4%). BPAR occurred in 8.2% of patients who showed significantly higher tacrolimus levels vs those without BPAR over the follow\u2010up (9.8\u00a0ng\/mL vs. 8.9\u00a0ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). Opportunistic infections were reported in 78.3% patients with BPAR vs 58.8% without BPAR (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.07). Quality of life improved across different domains of the Kidney Transplant Questionnaire and the ESRD\u2010SCL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study monitored clinical outcomes during the first year post\u2010transplant in older de novo kidney transplant recipients receiving grafts from older donors and under a once\u2010daily tacrolimus\u2010based immunosuppressive regimen. The incidence of BPAR, graft loss, and mortality was low, and patients generally experienced an improvement in quality of life, indicating an effective and safe procedure in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70501","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:32:14Z","timestamp":1773030734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes and Quality of Life in Older De Novo Kidney Transplant Recipients Under Once\u2010Daily Tacrolimus Formulations: The BITACORA Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1364","authenticated-orcid":false,"given":"Amado","family":"Andr\u00e9s","sequence":"first","affiliation":[{"name":"Nephrology Department Hospital Universitario 12 De Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital Universitario Ram\u00f3n y Cajal and Universidad de Alcal\u00e1 de Henares  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Aladr\u00e9n Regidor","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Moreso","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital Universitario Vall D'hebron and Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Crespo","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital Del Mar and Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Serra Caba\u00f1as","sequence":"additional","affiliation":[{"name":"Nephrology Department Fundaci\u00f3 Puigvert  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital Universitario Son Espases  Palma Illes Balears Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Nephrology Department Regional University Hospital of M\u00e1laga University of M\u00e1laga M\u00e1laga Biomedical Research Institute (IBIMA) \u2013 BIONAND Platform  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del","family":"Carmen D\u00edaz Corte","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital Universitario Central De Asturias. 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