{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:58:45Z","timestamp":1781816325513,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hematopoietic stem cell transplantation (HSCT) is widely used in both malignant and non\u2010malignant diseases in children. This study aimed to evaluate long\u2010term endocrine complications in pediatric HSCT survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children who underwent HSCT between April 2010 and October 2014 were retrospectively assessed. Data included demographics, growth and nutritional status, thyroid function, bone health, pubertal development, and gonadal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010five patients (45 males, 30 females; mean current age 18.8 \u00b1 3.9 years) were included. The mean follow\u2010up duration after HSCT was 9.7 \u00b1 1.2 years, and at least one endocrine disorder was identified in 40 patients (53.3%). At the last follow\u2010up, 23 patients (30.6%) were underweight, and 17 (18.6%) had short stature. Growth impairment was more frequent in patients with non\u2010malignant diseases. Hypothyroidism was observed in 6 patients (8%), and low bone mineral density (BMD)\/osteoporosis in 17 (22.6%). Short stature, malnutrition, low BMD, and vitamin D deficiency were more prevalent among those who underwent HSCT at \u226510 years of age. Hypogonadism was detected in 12 females (40%) and 11 males (24%) and showed no association with age at HSCT, pubertal stage, primary diagnosis, or conditioning regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings underscore the importance of long\u2010term endocrine surveillance in HSCT survivors, particularly in those transplanted at \u226510 years of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70504","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:02:42Z","timestamp":1773846162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Endocrine Effects of Hematopoietic Stem Cell Transplantation in Children: A Reappraisal"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-3950","authenticated-orcid":false,"given":"Dilek","family":"G\u00fcrlek G\u00f6k\u00e7ebay","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Bone Marrow Transplantation Unit University of Health Sciences Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-6546","authenticated-orcid":false,"given":"Gamze","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Health Sciences Ankara Bilkent City Hospital  Ankara Turkey"},{"name":"Department of Pediatric Hematology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Kanbur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Bone Marrow Transplantation Unit University of Health Sciences Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-8731","authenticated-orcid":false,"given":"\u0130kbal","family":"O. K. Bozkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Bone Marrow Transplantation Unit University of Health Sciences Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-3603","authenticated-orcid":false,"given":"Ozlem","family":"Arman Bilir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Bone Marrow Transplantation Unit University of Health Sciences Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-0681","authenticated-orcid":false,"given":"Namik Yasar","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Bone Marrow Transplantation Unit University of Health Sciences Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704853"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09864-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705531"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.10.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2016-0306"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12430"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02378.x"},{"key":"e_1_2_10_9_1","volume-title":"CDC Growth Charts Selected Percentiles and LMS Parameters","author":"National Center for Health Statistics","year":"2000"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2005.08.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31812f864d"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.210"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705694"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01204"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01755-x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(24)00167-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.39"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae196"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5603\/ahp.106922"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.01.003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.02.001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12876"},{"key":"e_1_2_10_24_1","first-page":"275","article-title":"Skeletal Effects of Estrogen","volume":"15","author":"Turner R. 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