{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:55:54Z","timestamp":1782132954920,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mycotic aneurysms (MA) are a potentially fatal complication following intestinal transplantation (ITx). Their occurrence arises from several factors, such as chronic abdominal sepsis, potential for contamination of the vascular grafts during enteric anastomoses and the heightened burden of immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of a prospectively maintained database of all adult ITx from December 2007 to June 2025 was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 168 ITx, six patients (3.6%) experienced eight MA episodes. MA occurred bimodally, early post\u2010transplant (2\u20138 weeks) or in a later phase (55\u2013377 weeks). Recurrence occurred in two patients, averaging 132.4 weeks after initial diagnosis. A history of hollow viscus perforation or anastomotic leak was present in 83.4%. Diagnosis was peri\u2010operative in two cases due to rupture, while others were detected electively via angio\u2010CT. Recurrences were subtler, identified incidentally or with mild symptoms. Apart from targeted antibiotic and antifungal treatment, management strategy pivoted around endovascular stent grafting (ESG) followed by an aneurysmectomy and creation of a new conduit. Post\u2010operative mortality at first presentation occurred in 66.6% of patients, with 50% within a week. Two patients survived recurrence, with one remaining alive 6.5\u00a0years post\u2010diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MA in ITx is rare but commonly fatal, often linked to bowel perforation or anastomotic complications. Diagnosis relies on angio\u2010CT or intraoperative identification at the time of emergency laparotomy. Management involves ESG and conduit resection. Early aggressive control of potential contamination sources after ITx is crucial, though general conclusions are limited by low incidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70545","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:08:43Z","timestamp":1778083723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mycotic Aneurysms in Intestinal Transplantation: A Case Series"],"prefix":"10.1111","volume":"40","author":[{"given":"Nicola","family":"Colucci","sequence":"first","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"},{"name":"Department of Surgery University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"De Gruttola","sequence":"additional","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry V. M.","family":"Spiers","sequence":"additional","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"},{"name":"Department of Surgery University of Cambridge  Cambridge UK"},{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation Cambridge Biomedical Research Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Geropoulos","sequence":"additional","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil K.","family":"Russell","sequence":"additional","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"},{"name":"Department of Surgery University of Cambridge  Cambridge UK"},{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation Cambridge Biomedical Research Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Winterbottom","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Upponi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Butler","sequence":"additional","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"},{"name":"Department of Surgery University of Cambridge  Cambridge UK"},{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation Cambridge Biomedical Research Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irum","family":"Amin","sequence":"additional","affiliation":[{"name":"Roy Calne Transplant Unit, Addenbrooke's Hospital Cambridge University Hospital NHS Foundation Trust  Cambridge UK"},{"name":"Department of Surgery University of Cambridge  Cambridge UK"},{"name":"NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation Cambridge Biomedical Research Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"20","article-title":"Current Status of Intestinal and Multivisceral Transplantation","volume":"5","author":"Bharadwaj S.","year":"2017","journal-title":"Gastroenterology Report (Oxford)"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.01.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.02.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.10.079"},{"key":"e_1_2_9_6_1","first-page":"65","article-title":"Intestinal Transplantation: A Coming of Age","volume":"36","author":"Abu\u2010Elmagd K.","year":"2002","journal-title":"Advances in Surgery"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182a9029a"},{"issue":"2","key":"e_1_2_9_8_1","article-title":"Endovascular Treatment of a Multi\u2010visceral Aortic Conduit Blowout With Parallel Stent Grafts and Coils","volume":"16","author":"Moris D.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvscit.2020.05.004"},{"key":"e_1_2_9_10_1","first-page":"207","article-title":"Intestinal Transplantation","volume":"6","author":"Fujiki M.","year":"2018","journal-title":"Published online December"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14249"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010018\u20104463\u20107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261982.76892.09"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae271"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12984"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009481"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.616654"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2323232"},{"key":"e_1_2_9_19_1","unstructured":"W. A.Hall H.Majeed andF.Ahmad.Mycotic Aneurysm. [Updated2025 Apr 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan\u2010.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK560736\/."}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70545","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:41:56Z","timestamp":1782132116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ctr.70545"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70545","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70545"}}