{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:55:49Z","timestamp":1782132949830,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether the difficulty of surgery affects failure\u2010to\u2010rescue (FTR) after liver transplantation (LT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary background data<\/jats:title>\n                    <jats:p>Predictors of FTR include both recipient and intraoperative factors, and their identification and improvement may reduce its incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included all first\u2010time isolated LTs performed in six centers. A difficult LT was defined as one in which the number of blood units transfused, cold ischemia time, and duration of surgery were all at or above the median values for the study population. FTR was defined as death within 90 days after a major postoperative complication. The correlations of a difficult LT with outcomes, including FTR, were assessed. Predictors of FTR were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population included 1341 patients. The respective incidences of difficult LT, 90\u2010day major complications, 90\u2010day mortality, and FTR were 17.4%, 53.6%, 5.8%, and 10.7%. Difficult LT was correlated with worse short\u2010term outcomes, including a high FTR rate. Being in the intensive care unit, receiving renal replacement therapy at the time of LT, and difficult LT were independent predictors of FTR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mortality following a difficult LT may be correlated to FTR. Identification of modifiable predictors of FTR may help to improve the post\u2010transplant management of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70551","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:07:02Z","timestamp":1777907222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Predictors of Failure\u2010to\u2010Rescue after Liver Transplantation: A Multicenter Analysis of 1341 Patients"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-6369","authenticated-orcid":false,"given":"Mehdi","family":"Boubaddi","sequence":"first","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetana","family":"Lim","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Unit\u00e9 De Recherche Clinique SSPC Universit\u00e9 De Picardie\u2010Jules Verne  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Rayar","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique CHU Nice  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-0364","authenticated-orcid":false,"given":"Lluis","family":"Secanella","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazare","family":"Sommier","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-7264","authenticated-orcid":false,"given":"Claire","family":"Goumard","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Centre De Recherche De Saint\u2010Antoine (CRSA) INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Savier","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Centre De Recherche De Saint\u2010Antoine (CRSA) INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Turco","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique CHU Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chady","family":"Salloum","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire H\u00f4pital Universitaire Paul Brousse, Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8175-337X","authenticated-orcid":false,"given":"Florence","family":"Jeune","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Vila\u2010Tura","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Perdigao","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. Sorbonne Universit\u00e9 H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Herrero","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sulpice","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique CHU Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Llado","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary and Pancreatic Surgery and Liver Transplantation Hospital Universitari de Bellvitge, CIBERehd  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire H\u00f4pital Universitaire Paul Brousse, Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Scatton","sequence":"additional","affiliation":[{"name":"Service De Chirurgie H\u00e9pato\u2010biliaire et Transplantation H\u00e9patique, Assistance Publique \u2010 H\u00f4pitaux de Paris. 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