{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:58:44Z","timestamp":1791536324088,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG076834"],"award-info":[{"award-number":["R01AG076834"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG077888"],"award-info":[{"award-number":["R01AG077888"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K02AG076883"],"award-info":[{"award-number":["K02AG076883"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG055781"],"award-info":[{"award-number":["R01AG055781"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK114074"],"award-info":[{"award-number":["R01DK114074"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK120518"],"award-info":[{"award-number":["R01DK120518"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24AI144954"],"award-info":[{"award-number":["K24AI144954"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hyperparathyroidism (HPT) commonly persists following kidney transplant (KT) and can result in bone alterations. However, the association between persistent HPT post\u2010KT and fracture risk is not well\u2010understood. We sought to quantify the association between persistent HPT at 1\u2010year post\u2010KT and fracture risk among KT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We leveraged a longitudinal prospective cohort of 344 adult KT recipients who underwent KT at a single institution (12\/2008\u201307\/2019). PTH levels were retroactively abstracted, and fractures after 1\u2010year\u2010post\u2010KT were ascertained using ICD\u20109\/ICD\u201010 codes. Competing risk models were used to estimate the association between persistent HPT (PTH \u2265 70 pg\/mL) at 1\u2010year post\u2010KT and the risk of fracture, with death treated as a competing event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 344 KT recipients, 227 (66.0%) had persistent HPT at 1\u2010year post\u2010KT. After adjusting for confounders, HPT 1\u2010year after KT was associated with a 3.11\u2010fold increased risk of fractures (95% CI: 1.08\u20138.91). There were no differences in this association by age, sex, race, eGFR at 1\u2010year\u2010post\u2010KT, osteoporosis at KT, or dialysis vintage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Recipients with HPT 1\u2010year after KT had a significantly higher risk of fractures than those without persistent HPT. Future studies should establish standardized practice guidelines for the treatment of persistent HPT to mitigate fracture\u2010related morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70553","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:00:23Z","timestamp":1777600823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Post\u2010Kidney Transplant Persistent Hyperparathyroidism and Fracture Risk: A Longitudinal Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6446-6434","authenticated-orcid":false,"given":"Rachel","family":"Stemme","sequence":"first","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-4817","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-1306","authenticated-orcid":false,"given":"Jingyao","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-5740","authenticated-orcid":false,"given":"Yiting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-8179","authenticated-orcid":false,"given":"Joy Zhou","family":"Done","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-2907","authenticated-orcid":false,"given":"Jennine","family":"Weller","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8960-2428","authenticated-orcid":false,"given":"Anatoliy V.","family":"Rudin","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-7455","authenticated-orcid":false,"given":"Daniel C.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-8687","authenticated-orcid":false,"given":"Lilah F.","family":"Morris\u2010Wiseman","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-4801","authenticated-orcid":false,"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine  New York New York USA"},{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-925X","authenticated-orcid":false,"given":"Mara A.","family":"McAdams\u2010DeMarco","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine  New York New York USA"},{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-7433","authenticated-orcid":false,"given":"Aarti","family":"Mathur","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.01.012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12425"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a6bbda"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1047\u20102797(01)00226\u20105"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12621"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100474"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15962"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115554"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223\u2010021\u201000837\u20100"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/15\u2010127"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2017.04.001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2024.12312"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201019\u20100284"},{"issue":"4","key":"e_1_2_12_15_1","first-page":"573","article-title":"Risk Factors of Post Renal Transplant Hyperparathyroidism","volume":"20","author":"Hamidian Jahromi A.","year":"2009","journal-title":"Saudi Journal of Kidney Diseases and Transplantation"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.11.020"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.12.030"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14085"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010015\u20101117\u2010z"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010019\u201001074\u20104"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.07.015"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12911"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015060622"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004538"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272\u20106386(03)00415\u20103"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2022.07.031"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000823"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005946"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010025\u201002723\u20107"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021081081"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.02.043"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2021.07.008"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1161093"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz062"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.03.067"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.09.030"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12666"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001449"},{"key":"e_1_2_12_40_1","volume-title":"UpToDate","author":"Yarlagadda S. G.","year":"2026"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh128"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030654"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.12.024"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.008"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2007.01950.x"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000368"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11371015"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2024.1939"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136528"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533125"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261686"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70237"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab239"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2011.03872.x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080851"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i2.370"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.14301"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.11.5249"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:41:32Z","timestamp":1782132092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ctr.70553"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70553","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70553"}}