{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:56:07Z","timestamp":1782132967408,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypothermic oxygenated machine perfusion (HOPE) is occasionally used to overcome logistical issues and allow longer cold preservation time (CPT); however, reports regarding these situations in older brain\u2010dead donors are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective analysis of kidney transplants (KTs) performed between January 1, 2015, to December 31, 2023, from extended criteria donors (ECDs) switched to HOPE after a median time of 17.1\u00a0h in static cold storage (SCS) for unexpected logistic reasons and with a median total CPT of 28.6\u00a0h (25.3\u201332.0) (\n                      <jats:italic>n<\/jats:italic>\n                      = 44, HOPE ECDs), compared with a control group of KTs (\n                      <jats:italic>n<\/jats:italic>\n                      = 44, L\u2010ECDs) maintained in SCS alone with a low CPT (median, 10.4 h; range, 7.1\u201311.1) and matched for age, sex, donor age, donor eGFR, pre\u2010emptive transplant, and cPRA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No primary nonfunction was observed, and both death\u2010censored graft survival (DCGS) and renal function progressively improved, remaining satisfactory and superimposable between groups up to two years post\u2010transplant (97.7% of DCGS with mean eGFR 46.5\u00a0mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      [36\u201355.65] in HOPE\u2010ECDs) versus 97.7% with 42.0 (30.2\u201348.2) in L\u2010ECDs with similar KDPI (67% [49.75\u201386.5] vs. 72.5% [60.5\u201387.75],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.475). These results were achieved in patients with HOPE\u2010ECDs, who experienced higher rates of DGF (31.8%\u00a0vs. 11.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036). No differences were noted in infection or rejection rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rescue by HOPE after SCS in ECDs with a very long CPT can achieve midterm outcomes similar to those with a low CPT in SCS alone, paving the way for its safe implementation in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70557","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:09:57Z","timestamp":1778303397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rescue by Hypothermic Oxygenated Machine Perfusion for Unexpected Long Prolongation of Cold Preservation Time in Expanded Criteria Donor Kidneys Can Achieve Favorable 2\u2010Year Outcomes"],"prefix":"10.1111","volume":"40","author":[{"given":"Silvia","family":"Mingozzi","sequence":"first","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mella","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Dolla","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Gallo","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Manzione","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Sanna","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Randone","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Tarragoni","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Giraudi","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Giovinazzo","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Melloni","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery Department of Thoracic\u2010Vascular Surgery Citt\u00e0 Della Salute e Della Scienza Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Verri","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery Department of Thoracic\u2010Vascular Surgery Citt\u00e0 Della Salute e Della Scienza Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bosio","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgical Sciences AOU Citt\u00e0 Della Salute e Della Scienza, Torino School of Medicine  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gontero","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgical Sciences AOU Citt\u00e0 Della Salute e Della Scienza, Torino School of Medicine  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Barreca","sequence":"additional","affiliation":[{"name":"Pathology Unit University of Turin, Citt\u00e0 Della Salute e Della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Fop","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d,Division of Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e Della Scienza\u201d Hospital, University of Turin, Italy  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-6350","authenticated-orcid":false,"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. 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