{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:56:07Z","timestamp":1782132967479,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the human pegivirus 1 (HPgV\u20101) infection is highly prevalent in immunocompromised populations, the effects of the infections on clinical outcomes in leukemia patients after stem cell transplantation (HSCT) are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 16 acute lymphoblastic leukemia (ALL) patients with allogeneic HSCT (allo\u2010HSCT) were included in this matched case\u2010control study and 1\u2010year survival outcomes were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One\u2010year survival analysis showed that HPgV\u20101 infections could significantly decrease overall survival (OS), but non\u2010significant differences in acute graft\u2010versus\u2010host disease (GVHD) grade III\u2010IV, severe chronic GVHD, leukemia relapse, progression\u2010free survival (PFS), and GVHD\u2010free relapse\u2010free survival (GRFS) were observed when compared with those without HPgV\u20101 infections. The infections also did not significantly impact the immune reconstitution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that HPgV\u20101 infections can decrease overall survivals in ALL patients at 1 year after allo\u2010HSCT, which provides a foundation for larger, prospective, case\u2010control studies to evaluate the overall effects of HPgV\u20101 infection on survival outcomes of leukemia patients with allo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70558","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:23:16Z","timestamp":1778682196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of HPgV\u20101 Infections on Clinical Outcomes in Patients With Acute Lymphoblastic Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: A Matched Case\u2010Control Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Zhanjia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine 5<sup>th<\/sup> Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Li","sequence":"additional","affiliation":[{"name":"Senior Department of Hematology 5<sup>th<\/sup> Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine 5<sup>th<\/sup> Medical Center of Chinese PLA General Hospital  Beijing 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