{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:55:57Z","timestamp":1782132957697,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To evaluate donor\u2010stratified graft and patient survival following kidney transplantation (KT) for lithium\u2010associated end\u2010stage kidney disease (ESKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective analysis utilized the Organ Procurement and Transplantation Network database. Adult KT recipients (January 1, 2015\u2013December 30, 2024) with lithium\u2010associated nephrotoxicity as the primary listing diagnosis (\n                      <jats:italic>n<\/jats:italic>\n                      = 840) were compared with those transplanted for other etiologies. Deceased\u2010donor (DDKT;\n                      <jats:italic>n<\/jats:italic>\n                      = 584) and living\u2010donor (LDKT;\n                      <jats:italic>n<\/jats:italic>\n                      = 256) cohorts were propensity matched 1:1 within donor type. Gompertz parametric survival models were selected after proportional hazards violation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 851 days (DDKT) and 1262 days (LDKT). Matched DDKT recipients with lithium\u2010associated ESKD had a lower prevalence of body mass index greater than 35\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (16.8%\u00a0vs. 21.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.047), lower calculated panel reactive antibody (17.45 \u00b1 30.58\u00a0vs. 27.85 \u00b1 37.48,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and lower private insurance coverage (20.4%\u00a0vs. 27.9%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). Lithium toxicity independently predicted reduced graft failure (HR, 0.668; 95% CI, 0.490\u20130.912;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011) and mortality (HR, 0.667; 95% CI, 0.483\u20130.921;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014). No other covariate retained independent significance in the adjusted model. Lithium\u2010associated ESKD did not predict graft failure or mortality among LDKT recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>KT for lithium\u2010associated ESKD was not associated with inferior outcomes. The favorable survival signal was confined to DDKT. It was more likely attributable to recipient\u2010level phenotypic differences and donor\u2010risk context than to any protective property of the underlying diagnosis. Posttransplant lithium dosing, compliance and rechallenge data are not captured in registry data and remain unmeasured.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70563","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:23:07Z","timestamp":1778858587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kidney Transplantation for Lithium Nephrotoxicity is Associated With Noninferior Graft and Patient Survival: A National Donor\u2010Stratified Registry Analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8220-867X","authenticated-orcid":false,"given":"Hannah","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Primary Care Touro College of Osteopathic Medicine  Middletown New York USA"},{"name":"Department of Surgery Garnet Health Medical Center  Middletown New York 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