{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:55:57Z","timestamp":1782132957729,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung transplant recipients (LTRs) can develop donor\u2010specific antibodies (DSAs), which are associated with antibody\u2010mediated rejection (AMR). LTRs at our center undergo regular DSA surveillance in the first year after lung transplant (LT), and LTRs that develop DSAs are treated, even in the absence of allograft dysfunction. We compared the clinical outcomes of LTRs without DSAs to those of LTRs that developed DSAs early after LT (&lt; 3 months) or late after LT (3\u201312 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 428 LTRs transplanted at our center between February 2017 and June 2022. Of these, 94 were included in the no\u2010DSA group (mean fluorescence intensity [MFI] &lt; 500) and 143 were included in the DSA groups (MFI \u2265 2000), with 131 in the early\u2010DSA group and 12 in the late\u2010DSA group. We compared the groups using Fisher's exact test, the median test, and Kaplan\u2013Meier and Cox regression survival analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant difference in 1\u2010 and 3\u2010year survival between the 3 groups; however, 3\u2010year survival in the late\u2010DSA group was 33%, with AMR as the cause of death in 2 of the 4 deceased LTRs. DSAs declined in the majority of patients in both the early and late groups. There were no significant differences in infectious complications between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.332).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LTRs with early DSAs and preemptive treatment have a good prognosis, with post\u2010LT overall survival and chronic lung allograft dysfunction (CLAD)\u2010free survival comparable to that of LTRs without DSAs. LTRs with late DSAs may have worse long\u2010term and CLAD\u2010free survival; however, larger studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70564","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:27:32Z","timestamp":1779193652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Implications of Early vs Late Development of Donor\u2010Specific Antibodies Among Lung Transplant Recipients: A Single\u2010Center Experience"],"prefix":"10.1111","volume":"40","author":[{"given":"Devika","family":"Sindu","sequence":"first","affiliation":[{"name":"School of Medicine Creighton University, Phoenix Regional Health Sciences Campus Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Pham","sequence":"additional","affiliation":[{"name":"Norton Thoracic Institute St. Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Kohler","sequence":"additional","affiliation":[{"name":"School of Medicine Creighton University, Phoenix Regional Health Sciences Campus Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Bitar","sequence":"additional","affiliation":[{"name":"School of Medicine Creighton University, Phoenix Regional Health Sciences Campus Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bowman","sequence":"additional","affiliation":[{"name":"Norton Thoracic Institute St. Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Grief","sequence":"additional","affiliation":[{"name":"Norton Thoracic Institute St. Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Walia","sequence":"additional","affiliation":[{"name":"School of Medicine Creighton University, Phoenix Regional Health Sciences Campus Arizona USA"},{"name":"Norton Thoracic Institute St. Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Franz","sequence":"additional","affiliation":[{"name":"Histocompatibility Laboratory, Vitalant  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya","family":"Tokman","sequence":"additional","affiliation":[{"name":"School of Medicine Creighton University, Phoenix Regional Health Sciences Campus Arizona USA"},{"name":"Norton Thoracic Institute St. Joseph's Hospital and Medical Center  Phoenix Arizona 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