{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:56:20Z","timestamp":1782132980700,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The use of pediatric donors in simultaneous pancreas\u2010kidney transplantation (SPKT) and solitary pancreas transplantation is not universally accepted<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single center retrospective review of 310 consecutive SPKTs and 50 solitary pancreas transplants performed from 11\/1\/01 to 1\/1\/25. All patients received depleting antibody induction with tacrolimus\/mycophenolate\/prednisone maintenance therapy. Pediatric donors were defined as age &lt;18 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the SPKT group, 72 patients (23.2%) received organs from donors &lt;18 years (mean 13.9 years), 215 from donors 18\u201340 years (mean 26.4 years), and 23 from donors &gt;40 years of age (mean 47.4 years). Rates of early pancreas thrombosis were 5.6%, 6.5%, and 4.3% (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.51), according to increasing donor age category. One\u2010year death\u2010censored pancreas and kidney graft survival rates (GSRs) were 93.0%, 92.0%, and 90.5%; and 98.6%, 99.1%, and 95.5%, respectively (both\n                      <jats:italic>p<\/jats:italic>\n                      = NS). Four\u2010year death\u2010censored pancreas GSRs were 87.9%, 78.7%, and 90.5%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.08). There were 11 pediatric donors \u226440\u00a0kg body weight (smallest 28\u00a0kg). One\u2010year patient, pancreas, and kidney GSRs were 100% and 4\u2010year patient and pancreas GSRs were 100% (kidney GSR 90%). There were no technical pancreas or kidney graft losses in the \u226440\u00a0kg donor group, and pancreas graft survival beyond 18 years has occurred. In 11 patients receiving solitary pancreas transplants from pediatric donors, there were no cases of early thrombosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite concerns related to small caliber vessels and donor\/recipient size mismatch, pediatric donors are associated with excellent mid\u2010term outcomes in SPKT recipients and may not represent a contraindication to pancreas utilization in solitary pancreas transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70575","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:26:07Z","timestamp":1779193567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Pediatric Donors in Pancreas Transplantation"],"prefix":"10.1111","volume":"40","author":[{"given":"Arianna","family":"Cabrales","sequence":"first","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen L.","family":"Jay","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Farney","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-094X","authenticated-orcid":false,"given":"Robert J.","family":"Stratta","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Transplantation Medical Center Blvd. Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14920"},{"key":"e_1_2_10_3_1","author":"Gruessner A.","year":"2026","journal-title":"Updated International Pancreas Transplant Registry (IPTR) data, personal communication"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/uro3020015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13890"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15148"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.01.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001736"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000001232"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198906000-00034"},{"key":"e_1_2_10_11_1","first-page":"441","article-title":"Combined Kidney and Pancreas Transplantation from Pediatric Donors into Adult Diabetic Recipients","volume":"26","author":"Abouna G. 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