{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:14Z","timestamp":1785779714500,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Elevated terminal donor creatinine often leads to kidney discard, although donor acute kidney injury (AKI) may represent reversible tubular injury. We evaluated the impact of donor AKI stage on delayed graft function (DGF), early graft recovery, and long\u2010term graft survival in a Japanese deceased\u2010donor kidney transplantation cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 50 consecutive deceased\u2010donor kidney transplants performed between 2010 and 2025. Donor AKI was classified according to the Kidney Disease: Improving Global Outcomes creatinine criteria. KDPI was calculated using the OPTN refit KDRI model (October 2024 implementation). DGF was defined as dialysis requirement within 7 days after transplantation. Death\u2010censored graft survival was analyzed using the Kaplan\u2013Meier method, and Cox proportional hazards modeling was performed as a univariate analysis due to the limited number of events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DGF occurred in 38 patients (76%). Higher donor AKI stage correlated significantly with DGF occurrence (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009 = \u20090.372,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 = \u20090.009), dialysis session count (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009 = \u20090.316,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 = \u20090.027), and lower eGFR at 3 months (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009 =\u2212\u20090.472,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt; \u20090.001) and 6 months (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009 = \u2212\u20090.408,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 = \u20090.004). During a median follow\u2010up of 75 months, four graft losses occurred. Death\u2010censored graft survival did not differ between AKI stage 0 and stages 1\u20133 (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009 = \u20090.90). Five\u2010 and 10\u2010year survival rates were 95.8% and 91.2%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Donor AKI was associated with increased early graft morbidity but not with inferior long\u2010term graft survival. Elevated terminal creatinine alone should not automatically preclude kidney utilization, particularly when reversible tubular injury is suspected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70581","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:40:07Z","timestamp":1779964807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Donor Acute Kidney Injury and Outcomes After Deceased Donor Kidney Transplantation: A 50\u2010Case Single\u2010Center Study From Japan"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-220X","authenticated-orcid":false,"given":"Yuki","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Surgery, Nephrology Center Toranomon Hospital Kajigaya  Kanagawa Japan"},{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Surgery, Nephrology Center Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nephrology Center Toranomon Hospital Kajigaya  Kanagawa Japan"},{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miruzato","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Surgery, Nephrology Center Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Toranomon Hospital Kajigaya  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiho","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Nephrology and Rheumatology, Nephrology Center Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kamiyama","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Surgery, Nephrology Center Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Ubara","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Nephrology and Rheumatology, Nephrology Center Toranomon Hospital Kajigaya  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sawa","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Nephrology and Rheumatology, Nephrology Center Toranomon Hospital Kajigaya  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ishii","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute For Medical Research Toranomon Hospital  Tokyo Japan"},{"name":"Department of Surgery, Nephrology Center Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13144"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13260"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.18634"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2008.02505.x"},{"key":"e_1_2_13_6_1","first-page":"182","article-title":"Delayed Graft Function: The AKI of Kidney Transplantation","volume":"13","author":"Mannon R. B.","year":"2018","journal-title":"Clinical Journal of American Society of Nephrology"},{"key":"e_1_2_13_7_1","first-page":"1","article-title":"KDIGO Clinical Practice Guideline for Acute Kidney Injury","volume":"2","author":"KDIGO Acute Kidney Injury Work Group","year":"2012","journal-title":"Kidney International Supplement"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac620b"},{"key":"e_1_2_13_9_1","unstructured":"Organ Procurement and Transplantation Network Guide to Calculating and Interpreting KDPI OPTN(2024) https:\/\/optn.transplant.hrsa.gov\/"},{"key":"e_1_2_13_10_1","first-page":"281","article-title":"A Note on Quantifying Follow\u2010Up in Studies of Failure Time","volume":"15","author":"Schemper M.","year":"1996","journal-title":"Statistics in Medicine"},{"key":"e_1_2_13_11_1","first-page":"2893","article-title":"Categories of Non\u2010Heart\u2010Beating Donors","volume":"27","author":"Kootstra G.","year":"1995","journal-title":"Transplantation Proceedings"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.12.091"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.03.088"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802289"},{"key":"e_1_2_13_15_1","first-page":"756","article-title":"Machine Perfusion Versus Cold Storage for the Preservation of Kidneys Donated After Cardiac Death","volume":"253","author":"Jochmans I.","year":"2011","journal-title":"Annals of Surgery"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13814"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2023.03.043"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:25:24Z","timestamp":1785777924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ctr.70581"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70581","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70581"}}