{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:15Z","timestamp":1785779715205,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) following lung transplantation is associated with long\u2010term outcomes. Although AKI is diagnosed based on absolute creatinine, this level may not reliably reflect kidney function due to reduced muscle mass in this population. Thus, this study investigated persistent kidney injury, defined by early creatinine trajectories, and its association with long\u2010term outcomes regardless of AKI diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study of adult lung\u2010transplant recipients, we used linear mixed\u2010effects models to compare first\u2010week creatinine trajectories between patients based on the development of adverse long\u2010term outcomes, specifically 2\u2010year chronic kidney disease (CKD) and major adverse kidney events (MAKE). We also assessed the association between Day 7\/Baseline Creatinine Ratio and these outcomes using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 150 recipients, 26% developed postoperative AKI. Although none had preoperative CKD, 60% of AKI patients and 40% of non\u2010AKI patients developed postoperative CKD. Those who developed CKD showed a significantly slower decline in creatinine over the first week compared to patients who did not (difference: 0.17\u00a0mg\/dL\/week,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), consistent in patients with and without AKI. Day 7\/Baseline Creatinine Ratio was significantly higher in patients with adverse outcomes and independently predicted both 2\u2010year CKD (Adjusted Odds Ratio: 4.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) and MAKE (Adjusted Odds Ratio: 3.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early persistent kidney injury was associated with adverse long\u2010term outcomes following lung transplantation, regardless of AKI diagnosis. Day 7\/Baseline Creatinine Ratio may serve as an early prognostic marker for risk stratification at the bedside or in clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70584","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:35:28Z","timestamp":1780562128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Persistent Kidney Injury and Long\u2010Term Outcomes Following Lung Transplantation"],"prefix":"10.1111","volume":"40","author":[{"given":"Kyosuke","family":"Dozono","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7388-9450","authenticated-orcid":false,"given":"Akinori","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine The University of Tokyo Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Intensive Care Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Inokuchi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine The University of Tokyo Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Clinical Engineering The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Komaru","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Konoeda","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine The University of Tokyo Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Clinical Engineering The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2401039"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620\u2010022\u201001392\u2010z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.07.024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001636"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.064"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072241"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800512"},{"key":"e_1_2_11_10_1","first-page":"1","article-title":"KDIGO Clinical Practice Guideline for Acute Kidney Injury","volume":"2","author":"Kellum J.","year":"2012","journal-title":"Kidney International Supplements"},{"issue":"4","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes CKDWG","year":"2024","journal-title":"Kidney International"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.06.028"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010025\u201007821\u20104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad107"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16439"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003671"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201506\u20101150OC"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02870707"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.06.072"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2024.07.016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.119"},{"key":"e_1_2_11_23_1","unstructured":"B.Koneswarakantha.easyalluvial: Generate Alluvial Plots With a Single Line of Code. R package version 0.4.0 2025 https:\/\/github.com\/erblast\/easyalluvial\/."},{"key":"e_1_2_11_24_1","unstructured":"K. A.Kassambara.ggpubr: \u2018ggplot2\u2019 Based Publication Ready Plots 2025 https:\/\/rpkgs.datanovia.com\/ggpubr\/."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.03167"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ\u20102021\u2010053"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjao.2024.100345"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11141113"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154097"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010199306000\u201000023"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010018\u20100946\u2010x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.12.017"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.08.010"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:25:22Z","timestamp":1785777922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ctr.70584"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70584","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70584"}}