{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:15Z","timestamp":1785779715146,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The effects of induction therapy with the anti\u2010CD52 monoclonal antibody alemtuzumab on age\u2010specific outcomes following kidney transplantation (KT) remain inadequately studied. This study aimed to analyze the comparative safety and efficacy of single\u2010dose alemtuzumab induction in deceased donor (DD) KT recipients according to different recipient age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010center retrospective nonrandomized cohort review of DDKT recipients stratified by age (30\u201349\/50\u201369\/70 years). All patients received a single 30\u2010mg intra\u2010operative dose of alemtuzumab. Standardized management algorithms were used. All patients received triple maintenance immunosuppression with tacrolimus\/mycophenolate\/steroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From September 2012 to December 2018, 723 DDKTs were performed with alemtuzumab induction. Donor age (33.1\u00a0\u00b1\u00a015.7\u00a0vs. 47.3\u00a0\u00b1\u00a016.0\u00a0vs. 53.3\u00a0\u00b1\u00a013.4 years;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and kidney donor profile index (KDPI, 46.5\u00a0\u00b1\u00a025.1\u00a0vs. 65.5\u00a0\u00b1\u00a023.8\u00a0vs. 74.4\u00a0\u00b1\u00a020.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) increased with increasing recipient age groups. Overall patient (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and graft (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) but not death\u2010censored graft survival (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.6) rates decreased with increasing recipient age strata. Rates of delayed graft function, biopsy\u2010proven acute rejection, and infectious complications at 1\u2010year post\u2010transplant were comparable amongst groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In DDKT recipients, alemtuzumab induction does not appear to confer excess risk of graft failure, acute rejection, or short\u2010term infectious complications in older patients relative to younger counterparts in the setting of triple maintenance immunosuppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70587","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:06:13Z","timestamp":1781251573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes Following Alemtuzumab Induction in Deceased Donor Kidney Transplantation According to Recipient Age Categories: A Single Center Report"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5650-2921","authenticated-orcid":false,"given":"Alex","family":"Ng","sequence":"first","affiliation":[{"name":"Urologic Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-4331","authenticated-orcid":false,"given":"David I.","family":"Harriman","sequence":"additional","affiliation":[{"name":"Urologic Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2074-7457","authenticated-orcid":false,"given":"Alan C.","family":"Farney","sequence":"additional","affiliation":[{"name":"Surgery,\u00a0Section of Transplantation Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-7974","authenticated-orcid":false,"given":"Giuseppe","family":"Orlando","sequence":"additional","affiliation":[{"name":"Surgery,\u00a0Section of Transplantation Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-2617","authenticated-orcid":false,"given":"Colleen","family":"Jay","sequence":"additional","affiliation":[{"name":"Surgery,\u00a0Section of Transplantation Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Reeves\u2010Daniel","sequence":"additional","affiliation":[{"name":"Internal Medicine, Section of Nephrology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0143-9813","authenticated-orcid":false,"given":"Robert J.","family":"Stratta","sequence":"additional","affiliation":[{"name":"Surgery,\u00a0Section of Transplantation Wake Forest University School of Medicine  Winston\u2010Salem North Carolina 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