{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:12Z","timestamp":1785779712154,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Near\u2010infrared spectroscopy (NIRS) provides a continuous and noninvasive method for assessing hepatic graft oxygenation. Establishing reference LSrO\n                      <jats:sub>2<\/jats:sub>\n                      values and evaluating their correlation with perfusion\u2010related parameters may improve early detection of vascular complications after living donor liver transplantation (LDLT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To determine the clinical utility of NIRS for early postoperative graft monitoring after LDLT and to define physiological hepatic LSrO\n                      <jats:sub>2<\/jats:sub>\n                      values in healthy individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective observational study included 83 adult LDLT recipients and 30 healthy volunteers. Volunteers underwent single\u2010time hepatic LSrO\n                      <jats:sub>2<\/jats:sub>\n                      assessment to establish reference values. In recipients, continuous NIRS monitoring of liver regional oxygen saturation (LSrO\n                      <jats:sub>2<\/jats:sub>\n                      ) was performed during the first 48 postoperative hours. Correlations between LSrO\n                      <jats:sub>2<\/jats:sub>\n                      and hemodynamic, laboratory, and Doppler parameters were evaluated at 3, 12, 24, and 48 h. ROC analysis was used to determine a diagnostic threshold of LSrO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Healthy volunteers demonstrated a mean hepatic LSrO2 of\u00a076.8 \u00b1 0.89\u00a0(95% CI: 76.47\u201377.13). LDLT recipients had significantly lower LSrO\n                      <jats:sub>2<\/jats:sub>\n                      values (74.49 \u00b1 3.74, 95% CI: 73.66\u201375.32;\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt; 0.001). LSrO\n                      <jats:sub>2<\/jats:sub>\n                      correlated positively with hemoglobin (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.507 at 24\u00a0h), hepatic artery flow velocity (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.328 at 24\u00a0h), and platelet count (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.401 at 48\u00a0h), and inversely with lactate (\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.329 at 24\u00a0h). A cutoff LSrO\n                      <jats:sub>2<\/jats:sub>\n                      value of\u00a072%\u00a0predicted perfusion\u2010related complications with an AUC of\u00a00.76\u00a0(95% CI: 0.4319\u20131.0000), sensitivity\u00a068.8%, specificity\u00a082.1%, and a Youden index of\u00a00.51.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      NIRS demonstrated promise as a reliable adjunct method for early postoperative graft monitoring following LDLT. LSrO\n                      <jats:sub>2<\/jats:sub>\n                      values below 72% may indicate early perfusion impairment. Establishing reference LSrO\n                      <jats:sub>2<\/jats:sub>\n                      values in healthy volunteers enhances the interpretability of postoperative measurements and supports the integration of NIRS into standard monitoring protocols.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70589","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:46Z","timestamp":1780921786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Near\u2010Infrared Spectroscopy (NIRS) for Early Postoperative Monitoring of Graft Oxygenation in Living Donor Liver Transplantation: A Prospective Observational Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-0802","authenticated-orcid":false,"given":"Ravshan","family":"Ibadov","sequence":"first","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center of Surgery named After Academician V. Vakhidov  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-5235","authenticated-orcid":false,"given":"Konstantin","family":"Semash","sequence":"additional","affiliation":[{"name":"National Children's Medical Center  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1179-6835","authenticated-orcid":false,"given":"Azimjon","family":"Usmonov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center of Surgery named After Academician V. Vakhidov  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-411X","authenticated-orcid":false,"given":"Sardor","family":"Ibragimov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center of Surgery named After Academician V. Vakhidov  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-7242","authenticated-orcid":false,"given":"Arsen","family":"Popov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center of Surgery named After Academician V. Vakhidov  Tashkent Uzbekistan"},{"name":"Department of Surgery Research Institute \u2013 Regional Clinical Hospital No. 1 Named After Professor S. V. Ochapovsky  Krasnodar, Krasnodarskiy Kray Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-787X","authenticated-orcid":false,"given":"Aleksei","family":"Lishchenko","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center of Surgery named After Academician V. Vakhidov  Tashkent Uzbekistan"},{"name":"Department of Surgery Research Institute \u2013 Regional Clinical Hospital No. 1 Named After Professor S. V. Ochapovsky  Krasnodar, Krasnodarskiy Kray Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8857-947X","authenticated-orcid":false,"given":"Timur","family":"Dzhanbekov","sequence":"additional","affiliation":[{"name":"National Children's Medical Center  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-6052","authenticated-orcid":false,"given":"Oybek","family":"Omonov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center of Endocrinology named After Yo. Kh. 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