{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:22:49Z","timestamp":1792135369186,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Pneumocystis jirovecii<\/jats:italic>\n                      is an opportunistic fungus responsible for Pneumocystis pneumonia (PJP) in hosts with impaired cell\u2010mediated immunity, particularly solid organ transplant recipients. The aim of our study was to identify risk factors associated with PJP in kidney transplant recipients (KTRs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center, retrospective, case\u2010control study (1 case per 2 controls) of KTRs from May 2014 to May 2024. Cases were defined as KTRs with a confirmed diagnosis of PJP, while controls were matched on transplant and hospitalization dates (\u00b13 months) and had not developed PJP during the follow\u2010up period. Statistical analysis was performed using conditional logistic regression models to examine potential risk factors for PJP, with a forward stepwise selection procedure to identify significant variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 37 KTRs with PJP and 74 matched controls were included. The median time from transplantation to diagnosis was 60 months. Two cases occurred before prophylaxis was discontinued, followed by 11 cases within the next six months. Baseline characteristics were similar between cases and controls. The number of day hospital or outpatient visits in the year prior to inclusion was significantly higher in cases than in controls (mean 11.11 vs. 8.89 visits,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04). Severe lymphopenia (&lt;0.5 G\/L) was the most significant risk factor for the development of PJP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The most significant risk factor observed was severe lymphopenia. These findings underscore the importance of strengthening infection prevention measures, including strict adherence to standard precautions, appropriate isolation protocols, and targeted prophylaxis for high\u2010risk individuals during periods of increased transmission. Further studies are needed to optimize PJP prophylaxis for KTRs with severe lymphopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70595","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:14:11Z","timestamp":1781252051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk Factors for\n                    <i>Pneumocystis Jirovecii<\/i>\n                    Pneumonia Among Kidney Transplant Recipients in Southeast France: A 10 Years Case\u2010Control Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Solenne","family":"Hulot","sequence":"first","affiliation":[{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection AP\u2010HM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Godefroy","sequence":"additional","affiliation":[{"name":"Centre De N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital Conception Assistance Publique H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Doudier","sequence":"additional","affiliation":[{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection AP\u2010HM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Delorme","sequence":"additional","affiliation":[{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection AP\u2010HM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Cortaredona","sequence":"additional","affiliation":[{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection AP\u2010HM  Marseille France"},{"name":"RITMES Aix\u2010Marseille Universit\u00e9, AP\u2010HM, SSA  Marseille France"},{"name":"MINES Aix\u2010Marseille Univ, IRD, SSA  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Sartor","sequence":"additional","affiliation":[{"name":"Service De Pr\u00e9vention du Risque Infectieux (LESPRI), CLIN AP\u2010HM H\u00f4pitaux Universitaires De Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"L'Ollivier","sequence":"additional","affiliation":[{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection AP\u2010HM  Marseille France"},{"name":"RITMES Aix\u2010Marseille Universit\u00e9, AP\u2010HM, SSA  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Burtey","sequence":"additional","affiliation":[{"name":"Centre De N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital Conception Assistance Publique H\u00f4pitaux de Marseille  Marseille France"},{"name":"Facult\u00e9 De pharmacie, C2VN Aix Marseille Univ, INSERM, INRAE  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Moal","sequence":"additional","affiliation":[{"name":"Centre De N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital Conception Assistance Publique H\u00f4pitaux de Marseille  Marseille France"},{"name":"MEPHI Aix Marseille Univ. 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