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LCPT offers a particular extended\u2010release formulation, potentially improving the concentration\u2010dose (C\/D) ratio and renal outcomes. This study investigated the impact of switching from standard\u2010release Tacrolimus (SR\u2010Tac) to LCPT on C\/D ratio and renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>170 adult LT recipients (August 2008\u2013March 2020) treated with tacrolimus for at least two years were included. In this single\u2010center, retrospective analysis, 63 patients converted to LCPT, while 107 patients continued on SR\u2010Tac. Clinical data were collected every three months over 24 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, median C\/D ratios were similar between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.553), the LCPT group showed significantly higher C\/D ratios compared to SR\u2010Tac during both the first (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) and second year (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). While LCPT\u2010treated patients showed an increased mean estimated glomerular filtration rate (eGFR), the SR\u2010Tac group exhibited a progressive decline at each follow\u2010up (mean decline: \u22125.4\u00a0mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      at 24 months,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Logistic regression identified switch to LCPT (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), female sex (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.043), and baseline eGFR (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038) as significant predictors of eGFR change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Conversion to LCPT may improve renal function in LT recipients over two years, suggesting potential long\u2010term nephroprotection without compromising graft function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70602","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:54:10Z","timestamp":1782208450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conversion to LCP Tacrolimus Mitigates Calcineurin\u2010Induced Nephrotoxicity in Patients After Liver Transplantation"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-7560","authenticated-orcid":false,"given":"Maximilian Joseph","family":"Brol","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Munske","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-3166","authenticated-orcid":false,"given":"Iyad","family":"Kabar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9248-1821","authenticated-orcid":false,"given":"Philipp Stephan","family":"Althaus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-6064","authenticated-orcid":false,"given":"Wenyi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-2887","authenticated-orcid":false,"given":"Frank Erhard","family":"Uschner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-9956","authenticated-orcid":false,"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Sebastian","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-1949","authenticated-orcid":false,"given":"Andreas","family":"Pascher","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2402-7764","authenticated-orcid":false,"given":"Hartmut H","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"},{"name":"Department of Hepatology, Gastroenterology and Transplantation Medicine University Hospital Essen  Essen 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