{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:24:31Z","timestamp":1790108671336,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK129845"],"award-info":[{"award-number":["R01DK129845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Digital behavioral interventions are promising to support patients\u2019 pursuit of live donor kidney transplantation (LDKT). This study examined the effectiveness of a patient\u2010led digital intervention (\n                      <jats:italic>KidneyTIME)<\/jats:italic>\n                      versus active control on facilitating LDKT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An individually randomized (1:1) parallel\u2010group trial was conducted at a safety\u2010net hospital transplant program with adult kidney transplant candidates in referral, evaluation, or listed phases who were English\u2010speaking and had email or text access.\n                      <jats:italic>KidneyTIME<\/jats:italic>\n                      participants received animated video LDKT education and outreach enablement via video sharing. The primary outcome was \u22651 live donor inquiry within 12 months in the intent\u2010to\u2010treat population. Secondary outcomes included LDKT knowledge, attitudes, behaviors toward listing and donor outreach, extent of video sharing, and intervention acceptability assessed by survey at 4 timepoints post\u2010exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 4\/22 and 7\/23, 422 candidates (mean age 54 years; 57% male, 45% income &lt; $30,000) were randomized to\n                      <jats:italic>KidneyTIME<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 212) or active control (\n                      <jats:italic>n<\/jats:italic>\n                      = 210). Between\u2010group differences in donor outreach behaviors and receipt of a donor inquiry were not detected.\n                      <jats:italic>KidneyTIME<\/jats:italic>\n                      participants had higher LDKT knowledge (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), new listing behaviors (IRR:1.62,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), and extent of video sharing (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016). In planned as\u2010treated analysis, intervention participants who viewed at least one optional video had significantly higher cumulative donor inquiry probability than those who did not (viewer 22.9%; non\u2010viewer 9.8%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029). Intervention acceptability scores were high.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A digital intervention self\u2010administered by patients did not increase donor inquiries. Preliminary dose effect findings suggest the need to consider how to encourage people to engage more with the intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70608","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:55:58Z","timestamp":1782917758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomized Controlled Trial of a Digital Intervention (KidneyTIME) to Promote Live Donor Kidney Transplantation"],"prefix":"10.1111","volume":"40","author":[{"given":"Liise K.","family":"Kayler","sequence":"first","affiliation":[{"name":"Department of Surgery Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York  Buffalo New York USA"},{"name":"Transplant and Kidney Care Regional Center of Excellence Erie County Medical Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoru","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Schar School of Policy and Government George Mason University  Fairfax Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health &amp; Health Professions University at Buffalo, State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Surgery Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York  Buffalo New York USA"},{"name":"Transplant and Kidney Care Regional Center of Excellence Erie County Medical Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee B.","family":"Cadzow","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health &amp; Health Professions University at Buffalo, State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Noyes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health &amp; Health Professions University at Buffalo, State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Von Visger","sequence":"additional","affiliation":[{"name":"Transplant and Kidney Care Regional Center of Excellence Erie County Medical Center  Buffalo New York USA"},{"name":"Division of Nephrology, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Surgery Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York  Buffalo New York USA"},{"name":"Primary Care Research Institute, Department of Family Medicine University at Buffalo, State University of New York  Buffalo New York USA"},{"name":"Community Health Equity Research Institute University at Buffalo, State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Feeley","sequence":"additional","affiliation":[{"name":"Department of Communication University at Buffalo, State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13173"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v14.i2.101419"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000986"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03660807"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/15269248211002804"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.08.039"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.7182\/prtr.21.1.e008266m25jtr77v"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/txd.0000000000001041"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13471"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000002732"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526924816679844"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16262"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168239"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13961"},{"key":"e_1_2_14_16_1","unstructured":"Pew Research Center. 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