{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:36:34Z","timestamp":1786476994672,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cannabis use is increasingly prevalent in the United States, yet its impact on outcomes after heart transplantation remains uncertain. This retrospective cohort study using the TriNetX network, included adult heart transplant recipients between 2005 and 2025. Patients with documented cannabis\u2010related disorders prior to transplantation were compared with non\u2010users using 1:1 propensity score matching. Five\u2010year outcomes included all\u2010cause mortality, transplant\u2010related complications\u2014rejection\/failure\/infection, acute kidney injury (AKI), and calcineurin inhibitor\u2010associated cardiometabolic adverse effects. After matching, 1054 patients were included in each cohort. All\u2010cause mortality at five years was similar between cannabis users and non\u2010users (17.9%\u00a0vs. 17.8%; HR 0.99, 95% CI 0.82\u20131.22;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.99). At five years, cannabis use was associated with higher rates of transplant\u2010related complications (HR 1.49, 95% CI 1.31\u20131.70,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001), including rejection (HR 1.50,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001) and graft failure (HR 1.62,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001). Rates of transplant infection and AKI were similar between groups. New\u2010onset cardiometabolic adverse effects were more frequent among cannabis users (HR 1.53,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.004). In a re\u2010run analysis including cardiac allograft vasculopathy (CAV) as an additional outcome, CAV was substantially more frequent among cannabis users (HR 2.81, 95% CI 2.14\u20133.68;\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001). This study highlights an important signal that requires prospective investigation and may inform future transplant evaluation and policy.\n                  <\/jats:p>","DOI":"10.1111\/ctr.70613","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:12:39Z","timestamp":1783354359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cannabis use and Post\u2010Transplant Outcomes in Heart Transplant Recipients: A Propensity\u2010Matched Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Shivam","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Reading Hospital\u2010Tower Health  West Reading Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishay","family":"Patel","sequence":"additional","affiliation":[{"name":"Drexel University College of Medicine  West Reading Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Samat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Reading Hospital\u2010Tower Health  West Reading Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viraj","family":"Shah","sequence":"additional","affiliation":[{"name":"Vascular Biology Center Division of Cardiology Department of Medicine Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Reading Hospital\u2010Tower Health  West Reading Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.122.009488"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.03.024"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1282831"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002851"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002599"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.05.010"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:26:29Z","timestamp":1786476389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/ctr.70613"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70613","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70613"}}