{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:36:32Z","timestamp":1786476992268,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Roxadustat is an oral hypoxia\u2010inducible factor prolyl\u2010hydroxylase inhibitor. Recent studies have shown no inferiority of roxadustat compared to erythropoietin in chronic kidney disease and in post\u2010transplant patients. We evaluated roxadustat versus erythropoiesis\u2010stimulating agents (ESAs) in very early posttransplant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of the clinical course and laboratory changes in posttransplant patients treated with roxadustat (16 patients) or a high\u2010dose erythropoiesis\u2010stimulating agent (ESA) (16 patients) for anemia between March and September 2025. We compared haemoglobin, creatinine, lipid levels, and iron status. The therapy was started after the kidney transplant, respectively, after a median of 3.5 and two days. Every patient was followed up at two weeks, one month, two months, and three months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients treated with roxadustat showed a significantly greater and faster increase in Hb levels at 2 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.047) than the ESA group. After 2 weeks, we observed a significant difference in the need for blood transfusions between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029; 18.8% in the roxadustat group vs. 62.5% in the ESA group). No significant differences were observed in iron or inflammation status during the study. The roxadustat group achieved a significantly better lipid profile after one month (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 for cholesterol and LDL). During the follow\u2010up, no adverse events related to roxadustat were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Administration of oral roxadustat in very early post\u2010transplant patients is effective and safe, rapidly improving anemia and reducing the need for transfusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70617","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:52:49Z","timestamp":1783504369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Post\u2010Kidney Transplant Treatment With Roxadustat Ameliorates Anemia and Reduces Blood Transfusion Needs in Inflamed Patients: A Case\u2010Matched Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Paolo","family":"Randone","sequence":"first","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Valenza","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mella","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Fop","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Dolla","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Gallo","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Manzione","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mingozzi","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Tarragoni","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Sanna","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-6350","authenticated-orcid":false,"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Renal Transplant Center \u201cA. Vercellone\u201d, Nephrology, Dialysis and Renal Transplant Division, Department of Medical Sciences \u201cCitt\u00e0 Della Salute e della Scienza\u201d Hospital, University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2016.07.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a170b7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20106143.2003.00133.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010018\u20101054\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V11suppl_1s1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00810.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455166"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020389"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201022\u20105897"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.04.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa110"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535071"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2025.15033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"S.Yoshida T.Saito andK.Shibagaki \u201cChanges of Biomarkers for Erythropoiesis Iron Metabolism and FGF23 by Supplementation With roxadustat in Patients on Hemodialysis \u201d (2023) 3181 https:\/\/doi.org\/10.1038\/s41598\u2010023\u201030331\u20106.","DOI":"10.1038\/s41598-023-30331-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.06.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204611"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2006.01727.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31824b36fa"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011060546"},{"issue":"17","key":"e_1_2_10_22_1","first-page":"1821","article-title":"Review Series Transfusion\u2010related Red Blood Cell Alloantibodies: Induction and Consequences","volume":"133","author":"Tormey C. 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