{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:36:37Z","timestamp":1786476997896,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recurrent IgA nephropathy (IgAN) after kidney transplantation has been reported in up to 20%\u201360% of recipients, through incidence varies by surveillance strategy. We aimed to define the incidence and clinical impact of biopsy\u2010proven recurrence IgAN in a single center cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed retrospective review of renal allograft biopsies performed at UCLA between 2020 and 2025. A total of 1474 patients underwent kidney allograft biopsies for clinical reasons. 40 patients had biopsy\u2010proven recurrent IgAN and were included in analysis. Clinical, laboratory and histopathologic features at recurrence were analyzed for association with graft failure using Kaplan\u2010Meier. Time\u2010to event analyses were performed using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Biopsy\u2010proven recurrent IgAN was identified in 40 of 1474 for\u2010cause biopsy recipients (2.7%). Graft failure occurred in 10 of 40 patients (25.0%) over a median follow\u2010up of 5.57 years. Median time from recurrence to graft failure was 2.46 years. Graft loss was attributed primarily to recurrent IgAN in 7 patients (70.0%) and associated with rejection in 3 (30.0%). IFTA &gt;50% was the only significant predictor of graft failure (HR 4.00, 95% CI 1.12\u201314.27;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). Rising creatinine, proteinuria, hematuria, Asian race, and C3 bright deposition showed non\u2010significant trends toward worse graft survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this for\u2010cause biopsy cohort, clinically detected recurrent IgAN was associated with meaningful graft loss. Severe chronic injury at recurrence identified patients with poorer prognosis, although this likely reflects advanced nonspecific allograft damage rather than a recurrence\u2010specific mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70620","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:42:27Z","timestamp":1784817747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Graft Outcomes in For\u2010Cause Biopsy\u2010Proven Recurrent IgA Nephropathy After Kidney Transplantation: Rare but Clinically Meaningful"],"prefix":"10.1111","volume":"40","author":[{"given":"Pitchamon","family":"Inkong","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Division of Nephrology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik L.","family":"Lum","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Kim","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishreen","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphamai","family":"Bunnapradist","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011020164"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07420716"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1206793"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2021.100594"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06720810"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.028"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.06.021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010019\u20100189\u20103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272\u20106386(97)90031\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00910121"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506853"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg373"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02802-x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.15590920"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90456-X"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.8966"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14593"}],"container-title":["Clinical 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