{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:36:43Z","timestamp":1786477003505,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010transplant malignancy is a major determinant of long\u2010term outcomes after solid organ transplantation. Whether simultaneous pancreas\u2013kidney (SPK) transplantation confers a differential post\u2010transplant cancer risk compared With kidney transplantation alone (KA) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective propensity score\u2013matched cohort study of adult transplant recipients at three Mayo Clinic sites between 2001 and 2017. SPK recipients (\n                      <jats:italic>n<\/jats:italic>\n                      = 484) were matched 1:1 with KA recipients using propensity scores. The primary outcome was post\u2010transplant cancer incidence analyzed using Fine\u2013Gray competing risks regression with death as a competing event. Standardized incidence ratios (SIRs) were calculated relative to the US general population. Cox proportional hazards models with cancer modeled as a time\u2010varying covariate evaluated associations with mortality and death\u2010censored graft failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median follow\u2010up of 10 years, overall cancer incidence was similar between SPK and KA recipients (subdistribution hazard ratio [sHR] 0.80, 95% CI 0.63\u20131.02;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.07). The observed trend toward lower cancer incidence in SPK recipients was driven by a lower incidence of non\u2010melanoma skin cancer (NMSC) (sHR 0.72, 95% CI 0.53\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), which was attenuated after age adjustment (sHR 0.76,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.07). Incidence of other malignancies did not differ between groups. Compared with the US general population, cancer risk excluding NMSC was approximately twofold higher in both cohorts (SIR 2.18 for SPK vs. 2.23 for KA). Incident malignancy was strongly associated with increased mortality (HR 3.40 in KA and 2.07 in SPK) but not with a statistically significant increase in graft failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this propensity score\u2013matched cohort study, overall post\u2010transplant malignancy incidence was comparable between SPK and KA recipients. Both groups experienced substantially elevated cancer risk relative to the general population, and incident malignancy was strongly associated with mortality. These findings suggest that malignancy risk is driven primarily by shared immunologic and demographic factors rather than transplant type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70621","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:41:44Z","timestamp":1784817704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer Risk After Simultaneous Pancreas\u2010Kidney Transplantation Compared With Kidney Transplant Alone: A Propensity\u2010Matched Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Mohamad Amir","family":"Balloura","sequence":"first","affiliation":[{"name":"Department of Transplant Mayo Clinic Jacksonville  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mawaldi","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic Jacksonville  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Me","family":"Me","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Mayo Clinic Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-4479","authenticated-orcid":false,"given":"Napat","family":"Leeaphorn","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic Jacksonville  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2603-360X","authenticated-orcid":false,"given":"Rose Mary","family":"Attieh","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic Jacksonville  Jacksonville Florida 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