{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:19:45Z","timestamp":1787681985861,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney transplantation from hepatitis C virus (HCV) viremic deceased donors into HCV seronegative recipients helps to expand the donor pool. The optimal duration of direct acting antiviral (DAA) prophylaxis remains undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of all HCV seronegative adults who received a kidney transplant from an HCV nucleic acid test (NAT) positive deceased donor at the VA Portland Medical Center between September 2017 and March 2025 and were treated with sofosbuvir\/velpatasvir (SOF\/VEL) prophylaxis for 28 days postoperatively. The primary outcome was sustained virologic response 12 weeks after completion of prophylaxis (initial SVR12). Secondary outcomes at 1 year included HCV treatment success rate, biopsy proven acute rejection (BPAR), delayed graft function (DGF), eGFR, liver enzyme abnormalities, CMV and BK viremia, adverse events, and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty patients were included. The mean age was 62.8 \u00b1 10.9 years, 92% were male, mean EPTS was 63.7 \u00b1 29.2 and mean KDPI was 59.8 \u00b1 19.6. Initial SVR12 after completion of prophylaxis was achieved in 46\/50 (92%), out of which 2 patients had their SOF\/VEL prophylaxis extended to 12 weeks because of transient viremia. Four patients (8%) failed prophylaxis and required HCV treatment with all achieving SVR (100% overall SVR). DGF occurred in 16%, BPAR in 12%, CMV viremia in 18%, and BK viremia in 16%. Mean 1\u2010year eGFR was 57.7 \u00b1 18.7\u00a0mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . No DAA attributable adverse events were recorded. One\u2010year all\u2010cause mortality was 2% (1\/50) and was unrelated to HCV or DAA. Older age\u00a0(72.3 \u00b1 4.0\u00a0vs. 62.0 \u00b1 11.0 years,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.030)\u00a0and higher\u00a0Estimated Post Transplant Survival (EPTS)\u00a0scores\u00a0(86.5 \u00b1 19.1\u00a0vs. 61.8 \u00b1 29.3,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041)\u00a0correlated significantly with prophylaxis failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 4\u2010week SOF\/VEL prophylaxis regimen coupled with HCV RNA surveillance and treatment appears to be safe and effective in a Veterans Affairs population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70629","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:51:59Z","timestamp":1785423119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes After 4\u2010Week Course of Sofosbuvir\/Velpatasvir Therapy in Hepatitis C Seronegative Recipients of Kidneys From Hepatitis C Viremic Deceased Donors"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-7187","authenticated-orcid":false,"given":"Basheer Ahamad","family":"Kummangal","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Nephrology and Hypertension Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1014-0328","authenticated-orcid":false,"given":"Madelaine","family":"Hack","sequence":"additional","affiliation":[{"name":"Division of Abdominal Organ Transplantation VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Abdominal Organ Transplantation Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9965-8459","authenticated-orcid":false,"given":"Sri Abirami","family":"Selvam","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Nephrology and Hypertension Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-5971","authenticated-orcid":false,"given":"Christopher","family":"Connelly","sequence":"additional","affiliation":[{"name":"Division of Abdominal Organ Transplantation VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Abdominal Organ Transplantation Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-9361","authenticated-orcid":false,"given":"Justin","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Nephrology and Hypertension Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0214-5454","authenticated-orcid":false,"given":"Jay","family":"Pandav","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Nephrology and Hypertension Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo de","family":"Mattos","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Nephrology and Hypertension Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services VA Portland Health Care System  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Ziolko","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services VA Portland Health Care System  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services VA Portland Health Care System  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-8430","authenticated-orcid":false,"given":"Shehzad","family":"Rehman","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension VA Portland Health Care System  Portland Oregon USA"},{"name":"Division of Nephrology and Hypertension Oregon Health &amp; 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