{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:50:42Z","timestamp":1791345042789,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We used a national cohort to compare post\u2010transplant outcomes of lung\u2010kidney and lung\u2010liver transplantation to isolated lung transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The United Network for Organ Sharing database was queried for all lung transplants performed from 1\/1\/2010\u20109\/30\/2024. Heart\u2010lung and three\u2010organ transplants were excluded. Patients undergoing isolated lung transplantation were compared with those undergoing simultaneous lung\u2010kidney or lung\u2010liver transplantation. Cox proportional hazards models assessed factors associated with one and three\u2010year mortality. Temporal utilization trends were evaluated with linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 33,656 lung transplant recipients, 33,358 (99.1%) underwent isolated lung, 137 (0.4%) underwent lung\u2010kidney, and 161 (0.5%) underwent lung\u2010liver transplantation. One\u2010year patient survival was lower for lung\u2010kidney (79.7%) and lung\u2010liver (82.6%) compared to lung (88.3%;\n                      <jats:italic>log\u2010rank p<\/jats:italic>\n                      &lt; 0.001) but not at three years (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.101). Median survival was 6.3 (95% CI 6.2\u20106.4) years for lung, 6.2 (95% CI 4.3\u201010.0) years for lung\u2010kidney, and 9.5 (95% CI 4.8\u2010\u221e) years for lung\u2010liver (\n                      <jats:italic>log\u2010rank p<\/jats:italic>\n                      = 0.392). Following multivariable Cox risk adjustment, lung\u2010liver was associated with increased one\u2010year mortality (HR, 1.64; 95% CI, 1.11\u20102.41;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013) but not three\u2010year mortality (HR, 1.23; 95% CI, 0.90\u20101.67;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.187), while lung\u2010kidney was not associated with mortality at one (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.684) or three years (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.162). On linear regression, the incidence of lung\u2010kidney and lung\u2010liver both increased over the study period at a faster rate than lung transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although lung\u2010kidney and lung\u2010liver had lower one\u2010year survival, three\u2010year survival was not different compared to isolated lung transplantation after risk adjustment. Given inferior short\u2010term outcomes, multiorgan recipients, particularly lung\u2010kidney, require more sensitive patient selection to ensure equitable access to abdominal allografts. However, these findings cautiously support the viability and increased utilization of multiorgan lung transplantation in carefully selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70652","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:59:17Z","timestamp":1787817557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival and Outcomes of Lung\u2010Kidney and Lung\u2010Liver Transplants Using a Large National Cohort"],"prefix":"10.1111","volume":"40","author":[{"given":"John A.","family":"Treffalls","sequence":"first","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Pennington","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie C.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"Heimbach","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester Minnesota USA"},{"name":"William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Transplantation Surgery, Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Schinstock","sequence":"additional","affiliation":[{"name":"William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Nephrology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio A.","family":"Villavicencio","sequence":"additional","affiliation":[{"name":"William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Saddoughi","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester Minnesota USA"},{"name":"William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.08.047"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.03.010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2023.06.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002529"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481508101027"},{"key":"e_1_2_12_7_1","unstructured":"The jamovi project(Version 2.3). 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