{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:50:47Z","timestamp":1791345047285,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypothermic oxygenated machine perfusion (HOPE) is an alternative to static cold storage (SCS) for liver graft preservation, aiming to reduce ischemia\u2013reperfusion injury (IRI) and improve post\u2010transplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically reviewed randomized controlled trials (RCTs) comparing HOPE with SCS in adult liver transplantation (MEDLINE, EMBASE, CENTRAL to July 2026). Outcomes included early allograft dysfunction (EAD), primary non\u2010function (PNF), major postoperative complications, biliary complications, including non\u2010anastomotic strictures (NAS), graft survival, and retransplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight RCTs (984 patients; HOPE 461; SCS 523) met inclusion criteria. HOPE significantly reduced EAD (17.8%\u00a0vs. 33.5%; RR 0.54, 95% CI 0.43\u20130.68;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.00001) and PNF (0.4%\u00a0vs. 3.6%; RR 0.26, 95% CI 0.09\u20130.75;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). HOPE was associated with fewer major complications (Clavien\u2013Dindo \u2265 III) (41.2%\u00a0vs. 50.7%; RR 0.80, 95% CI 0.70\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003), lower overall biliary complications (18.9%\u00a0vs. 27.7%; RR 0.72, 95% CI 0.58\u20130.90;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and reduced NAS (3.3%\u00a0vs. 7.6%; RR 0.43, 95% CI 0.23\u20130.82;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). One\u2010year graft survival was comparable, while retransplantation was reduced after HOPE (RR 0.35, 95% CI 0.14\u20130.84,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HOPE improves early graft outcomes and reduces biliary morbidity and retransplantation compared with SCS, supporting its use to mitigate IRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70676","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:19:20Z","timestamp":1789024760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypothermic Oxygenated Perfusion Versus Static Cold Storage in Liver Transplantation: A Meta\u2010 Analysis of Randomized Trials"],"prefix":"10.1111","volume":"40","author":[{"given":"Ameni","family":"Ellouze","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Digestive Surgery University Hospital Rennes 1 University  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Tzedakis","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010biliary, Digestive and Endocrine Surgery Cochin Hospital, APHP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Ali","family":"Zorkot","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Digestive Surgery University Hospital Rennes 1 University  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Giudicelli","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Digestive Surgery University Hospital Rennes 1 University  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Boudjema","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Digestive Surgery University Hospital Rennes 1 University  Rennes France"},{"name":"Irset (Institut De Recherche En sant\u00e9, Environnement Et travail) \u2010UMR_S 1085 Inserm, EHESP, Univ Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heithem","family":"Jeddou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Digestive Surgery University Hospital Rennes 1 University  Rennes France"},{"name":"Irset (Institut De Recherche En sant\u00e9, Environnement Et travail) \u2010UMR_S 1085 Inserm, EHESP, Univ Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01242.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25462"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006491"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25859"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e86b11"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198804000-00001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.235"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02932.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25955"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16996"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12958"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001473"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10515"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14640"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031532"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005110"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17115"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.12.030"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006055"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000715"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.10.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2026.1604"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70291"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000784"},{"issue":"9","key":"e_1_2_9_26_1","article-title":"Machine 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