{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:50:44Z","timestamp":1791345044594,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Donor\/recipient HLA molecular mismatches are predictive of kidney transplant outcomes. Their role in pancreas transplantation has not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study in 281 pancreas (\u00b1 kidney) transplant recipients during 2000\u20132018, followed for average 53.8 months. T\u2010cell epitope matching was performed by the PIRCHE\u2010II algorithm (T2) and B\u2010cell epitope mismatch using Snow (B2) and HLA Matchmaker algorithms. Primary outcome was pancreas acute rejection, secondary outcomes included pancreas graft failure and composite of both, and kidney graft failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PIRCHE\u2010T2 score (59.3\u00b122.3) was not associated with study outcomes (HR 0.99, 95%CI 0.98\u20131.00,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.31 for pancreas rejection). However, increasing PIRCHE\u2010B score (15.1\u00b16.3) was predictive of lower risk of acute rejection (aHR 0.94; 95%CI 0.9\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.024) and graft failure (aHR 0.96; 95%CI 0.93\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021), driven by PIRCHE\u2010B\u2010Class II score (aHR 0.91; 95%CI 0.85\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01; aHR 0.92; 95%CI 0.88\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001, respectively). Total eplet mismatch (19.58\u00b17.40) was highly correlated with PIRCHE\u2010B score (\u03c1 = 0.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), showing similar associations. However, the molecular scores were not associated with kidney graft failure (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.57 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that higher B\u2010cell epitope mismatch loads are paradoxically associated with improved pancreas transplant outcomes, while PIRCHE\u2010T2 scores demonstrated limited predictive value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70677","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:17:11Z","timestamp":1789024631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Value of HLA\u2010Derived T\u2010Cell Epitope and B\u2010Cell Epitope Matching Algorithms for Pancreas Transplant Outcomes"],"prefix":"10.1111","volume":"40","author":[{"given":"Zakieh","family":"Zare","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Niemann","sequence":"additional","affiliation":[{"name":"PIRCHE  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Shirini","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Maryland Medical Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Dale","sequence":"additional","affiliation":[{"name":"Transplant Diagnostics Thermo Fisher Scientific  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ugarte","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke V.","family":"Niederhaus","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia B.","family":"Drachenberg","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolreza","family":"Haririan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland 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Procurement and Transplantation Network (OPTN).Definition of Pancreas Graft Failure. 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Accessed March 28 2026 https:\/\/unos.org\/wp\u2010content\/uploads\/Definition\u2010of\u2010Pancreas\u2010Graft\u2010Failure.pdf."}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70677","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:14:36Z","timestamp":1791342876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ctr.70677"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70677","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70677"}}