{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:50:43Z","timestamp":1791345043428,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Donor blood pH, recorded for nearly all heart donors, may reflect shock, but its value as an isolated predictor of outcomes is unestablished. The 2018 allocation change altered donor use and acuity, so its prognostic weight may be era\u2010dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied adult, first\u2010time, isolated heart transplant recipients in the OPTN\/UNOS registry (2015\u20132025), with donor blood pH classified as acidosis (&lt;7.35), normal (7.35\u20137.45), or alkalosis (&gt;7.45). The primary outcome was all\u2010cause mortality. A covariate\u2010adjusted Cox model tested the donor acid\u2010base\u2010by\u2010allocation\u2010era interaction. Secondary analyses examined short\u2010term mortality, contemporary mechanical circulatory support, allograft failure, dialysis, and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary model included 31,349 recipients and 5,962 deaths. Donor acidosis was associated with mortality before 2018 (hazard ratio 1.18, 95% CI 1.07\u20131.29) but not after (0.97, 0.86\u20131.09); the ratio of post\u2010 to pre\u20102018 hazard ratios was 0.82 (0.71\u20130.96; interaction\n                      <jats:italic>p =<\/jats:italic>\n                      0.010). The composite of allograft failure or death showed the same pattern (\n                      <jats:italic>p =<\/jats:italic>\n                      0.009). Continuous donor pH showed no significant association in either era. Among recipients transplanted on or after October 1, 2023, donor acidosis was associated with a higher adjusted risk of extracorporeal membrane oxygenation (risk ratio 1.52, 1.22\u20131.90) but not 90\u2010day mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among donor hearts selected for transplantation, donor acidosis was associated with mortality before but not after the 2018 allocation change, although it remained associated with greater mechanical circulatory support. These findings do not establish that all acidotic hearts are suitable or that donor pH can be disregarded; it remains one component of comprehensive donor assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70691","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:03:11Z","timestamp":1790035391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Donor Acidosis and Post\u2010Transplant Survival Across Heart Allocation Eras: A National Registry Analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Sajid","family":"Kadir","sequence":"first","affiliation":[{"name":"Pepin Heart Institute Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Sasidharan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine University of Florida College of Medicine \u2013 Jacksonville  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Perez","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ataul","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Aultman Hospital  Canton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swethika","family":"Sundaravel","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Belli","sequence":"additional","affiliation":[{"name":"Pepin Heart Institute Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.07.010"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010019\u20100999\u20107"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v11.i10.410"},{"issue":"8","key":"e_1_2_14_6_1","first-page":"1097","article-title":"Donor Selection in Heart Transplantation","volume":"6","author":"Kilic A.","year":"2014","journal-title":"Journal of thoracic 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