{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:50:44Z","timestamp":1791345044023,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>BK polyomavirus nephropathy (BKPyVN) is a well\u2010recognized cause of graft dysfunction and loss in kidney transplant recipients (KTRs). However, its clinical and pathological features in the native kidneys of non\u2010 KTRs remain poorly defined. We aimed to characterize native\u2010kidney BKPyVN and compare it with allograft BKPyVN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical, virological, pathological and prognostic features of native\u2010kidney BKPyVN. A 1:4 matched cohort of KTRs with allograft BKPyVN served as the control group. Diagnosis was established by kidney biopsy with SV40\u2010T immunohistochemical confirmation and supported by BKPyV DNA detection in urine and\/or plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine patients with native\u2010kidney BKPyVN were identified, including 6 who had undergone hematopoietic stem cell transplantation, 2 lung and 1 heart\u2010lung transplantation. All underwent kidney biopsy for progressive kidney dysfunction. At diagnosis, all had marked BKPyV DNAviruria, and plasma BKPyV DNA was detectable in 8 of 9 patients. Tubular basement membrane (TBM) C4d staining was observed in 8 of 9 cases and correlated with the extent of tubular SV40\u2010T positivity. Compared with allograft BKPyVN, native\u2010kidney BKPyVN presented with higher plasma BKPyV DNA levels, greater intrarenal viral load and more severe tubulointerstitial injury (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Kaplan\u2013Meier analysis showed lower 12\u2010month ESRD\u2010free survival in patients with native\u2010kidney BKPyVN than in those with allograft BKPyVN (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Native\u2010kidney BKPyVN is associated with advanced tubulointerstitial injury, frequent TBM C4d deposition and poor short\u2010term renal outcomes. The greater severity than allograft BKPyVN may largely reflect delayed diagnosis in the absence of routine BKPyV surveillance. Earlier BKPyV testing and timely kidney biopsy should be considered in high\u2010risk patients with otherwise unexplained kidney dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70693","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:21:02Z","timestamp":1790036462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Native Versus Allograft BK Polyomavirus Nephropathy: A Matched Cohort Study of Clinicopathological Features and Outcomes"],"prefix":"10.1111","volume":"40","author":[{"given":"Tong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Sun Yat\u2010sen university  Guangzhou China"},{"name":"Department of Nephrology The First Affiliated Hospital, Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Sun Yat\u2010sen university  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Nephrology Center of Kidney and Urology The Seventh Affiliated Hospital, Sun Yat\u2010sen university  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Sun Yat\u2010sen university  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital, Sun Yat\u2010sen university  Guangzhou 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