{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:51:51Z","timestamp":1791571911199,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Left ventricular hypertrophy in heart transplant recipients has been attributed to the use of calcineurin inhibitors. We assessed left ventricular mass across treatment arms in 83 heart transplant recipients in the Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE), and in 75 maintenance recipients in the Nordic Certican Trial in Heart and Lung Transplantation (NOCTET). In SCHEDULE, we randomized participants to treatment with calcineurin inhibitors or replacement with everolimus within 7\u201311 weeks after transplant. In NOCTET, participants were randomized to treatment with calcineurin inhibitors or a combination of low dose calcineurin inhibitors and everolimus. We followed patients with echocardiography for 3 years in the SCHEDULE trial and for 5 years in NOCTET. In SCHEDULE, left ventricular mass diminished with time, particularly across the first year of follow\u2010up (everolimus arm: \u221210 \u00b1 18\u00a0g\/m\n                      <jats:sup>2<\/jats:sup>\n                      , cyclosporine arm: \u22129 \u00b1 13\u00a0g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). However, there was no between\u2010group difference in this development (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.91). In NOCTET, there was no significant change in LVM over time and no between\u2010group difference in the change (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.27). In conclusion,\n                      <jats:bold>t<\/jats:bold>\n                      he replacement of calcineurin inhibitors with everolimus or a reduction in the calcineurin inhibitor dose did not mitigate left ventricular hypertrophy after heart transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>SCHEDULE\u2014ClinicalTrials.gov Identifier: NCT01266148; NOCTET\u2014ClinicalTrials.gov Identifier: NCT00377962<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70705","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:07:39Z","timestamp":1791569259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development in Left Ventricular Mass After Early and Late Conversion From Calcineurin Inhibitors to Everolimus in Heart Transplant Recipients\u2014Results From Two Randomized Controlled Trials"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-9673","authenticated-orcid":false,"given":"Klaus","family":"Murbraech","sequence":"first","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feben","family":"Tecklzig","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-0569","authenticated-orcid":false,"given":"Richard John","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-198X","authenticated-orcid":false,"given":"Einar","family":"Gude","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"KG Jebsen Center For Cardiac Research and Center for Heart Failure Research University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-341X","authenticated-orcid":false,"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-1924","authenticated-orcid":false,"given":"Hans","family":"Eiskj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-1191","authenticated-orcid":false,"given":"Kristjan","family":"Karason","sequence":"additional","affiliation":[{"name":"Transplant Institute Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-2771","authenticated-orcid":false,"given":"G\u00f6ran","family":"R\u00e5degran","sequence":"additional","affiliation":[{"name":"The Clinic for Heart Failure and Valvular Disease Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne K.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-6641","authenticated-orcid":false,"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"KG Jebsen Center For Cardiac Research and Center for Heart Failure Research University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-805X","authenticated-orcid":false,"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"KG Jebsen Center For Cardiac Research and Center for Heart Failure Research University of Oslo  Oslo 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