{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:12Z","timestamp":1792173372337,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Appropriate matching between donor nephron mass and recipient metabolic demand is increasingly recognized as an important determinant of kidney graft outcomes. However, practical and widely applicable methods for estimating graft\u2010recipient size matching remain limited. We investigated whether renal parenchymal volume measured by routine ultrasonography and normalized to recipient body mass index (BMI) is associated with kidney graft function one year after transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective single\u2010center study, adult kidney transplant recipients underwent routine ultrasonographic assessment one month after transplantation. Renal volumetric parameters, including total renal volume (TRV) and differential renal volume (DRV), were calculated and normalized to recipient BMI. Associations with estimated glomerular filtration rate (eGFR) at one year were evaluated using correlation and multivariable linear regression analyses adjusted for relevant donor and recipient characteristics. Receiver operating characteristic (ROC) analysis was performed to assess the discriminatory ability of the most informative volumetric index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Renal volumetric parameters were significantly associated with one\u2010year graft function, with stronger associations observed after normalization for recipient BMI. Among the evaluated indices, the DRV\/BMI ratio showed the strongest correlation with eGFR and remained independently associated with one\u2010year graft function after multivariable adjustment. Exclusion of renal sinus volume improved the predictive performance of volumetric assessment, supporting the relevance of functional renal parenchyma over total kidney volume. In exploratory ROC analysis, the DRV\/BMI ratio demonstrated good discrimination for preserved graft function (AUC 0.774), although the identified threshold requires external validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultrasound\u2010derived donor renal parenchymal volume indexed to recipient BMI represents a simple, non\u2010invasive, and clinically applicable surrogate of graft\u2010recipient size matching. If validated in larger multicenter cohorts, this approach may complement existing clinical parameters for predicting graft function and support more individualized post\u2010transplant management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70721","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:40:17Z","timestamp":1792172417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Derived Differential Renal Volume Indexed to Recipient Body Mass Index Predicts One\u2010Year Kidney Graft Function: A Novel Surrogate of Graft\u2013Recipient Size Matching"],"prefix":"10.1111","volume":"40","author":[{"given":"Iacopo","family":"Gianassi","sequence":"first","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Allinovi","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Caroti","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Di","family":"Maria","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Larti","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Antognoli","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Angela Di","family":"Pietro","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Cutruzzul\u00e0","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Allegretta","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Malatesta","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino Calogero","family":"Cirami","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1600-6143.2011.03686.x","article-title":"Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes","volume":"11","author":"Tonelli M.","year":"2011","journal-title":"American Journal of Transplantation"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1001\/jama.294.21.2726","article-title":"Deceased\u2010donor Characteristics and the Survival Benefit of Kidney Transplantation","volume":"294","author":"Merion R. M.","year":"2005","journal-title":"Jama"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.12.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2025.100965"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70596"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.juro.2010.09.098","article-title":"Donor Kidney Volume Predicts Recipient Function Following Live Donor Renal Transplantation","volume":"185","author":"Hugen C. M.","year":"2011","journal-title":"The Journal of Urology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235251"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1007175"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-015-0340-5","article-title":"Body Mass Index and Outcome in Renal Transplant Recipients: A Systematic Review and Meta\u2010analysis","volume":"13","author":"Lafranca J. A.","year":"2015","journal-title":"BMC Medicine"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.032"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/ndt\/gfp055","article-title":"Kidney Volume Measured by Ultrasonography Correlates With Renal Function in Chronic Kidney Disease","volume":"24","author":"Sanusi A. A.","year":"2009","journal-title":"Nephrology Dialysis Transplantation"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:40:19Z","timestamp":1792172419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ctr.70721"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70721","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70721"}}