{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:34:39Z","timestamp":1793208879069,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Escalating deaths associated with the opioid crisis has increased availability of transplant organs from donors who died of a drug overdose, yet perception of these organs as \u201cincreased risk\u201d contributes to their unnecessary discard. Previous research addressing this issue has focused solely on survival outcomes, but quality of life is also a crucial factor in determining transplant success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, a secondary analysis of data representing adult, first\u2010time heart transplant recipients from the Scientific Registry of Transplant Recipients between January 1, 2016, and March 1, 2020 was conducted. Logistic regression modeled one\u2010year survival and functional status at one\u2010year, and Cox proportional hazards modeled survival time post\u2010transplant. Non\u2010inferiority testing compared survival and functional status outcomes for overdose donor (\n                      <jats:italic>n<\/jats:italic>\n                      = 2240) and non\u2010overdose donor (\n                      <jats:italic>n<\/jats:italic>\n                      = 9427) organ recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When not controlling for significant covariates, one\u2010year survival rates, post\u2010transplant survival time, and one\u2010year Karnofsky scores were at least as good or better for overdose donor organ recipients compared to non\u2010overdose organ recipients based on a\u2010priori non\u2010inferiority thresholds; estimated OR for one\u2010year survival is 1.0207 (95% CI [0.863, 1.213]), estimated hazards ratio is 0.9425 (95% CI [0.823, 1.079]), and estimated OR for having high one\u2010year functional status is 0.9035 (95% CI [0.769, 1.066]). Controlling for significant covariates, one\u2010year survival (OR 0.9613, 95% CI [0.790, 1.176]) and functional status (OR 1.0181, 95% CI [0.855, 1.218]) remained at least as good or better for overdose donor recipients; survival time was also estimated to be as good or better for overdose organ recipients when controlling for significant covariates (HR 0.9611, 95% CI [0.828, 1.115]), but not to the level of statistical significance based on the non\u2010inferiority threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, post\u2010transplant survival times, one\u2010year survival rates, and one\u2010year functional status are similar for overdose and non\u2010overdose organ heart transplant recipients. These findings support a broader utilization of the drug overdose donor pool, especially as the demand for heart transplantation increases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70725","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:49:56Z","timestamp":1792774196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival and Functional Status Outcomes in Heart Transplant Recipients: An Analysis of Organs From Donors Who Overdosed"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9219-934X","authenticated-orcid":false,"given":"Jennifer L.","family":"Siebert","sequence":"first","affiliation":[{"name":"M. Louise Fitzpatrick College of Nursing Villanova University  Villanova Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-3826","authenticated-orcid":false,"given":"James D.","family":"Mendez","sequence":"additional","affiliation":[{"name":"M. Louise Fitzpatrick College of Nursing Villanova University  Villanova Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-1956","authenticated-orcid":false,"given":"Jennifer","family":"Yost","sequence":"additional","affiliation":[{"name":"M. Louise Fitzpatrick College of Nursing Villanova University  Villanova Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, College of Arts &amp; Sciences Villanova University  Villanova Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2026.05.715"},{"key":"e_1_2_11_3_1","volume-title":"Drug Overdose Deaths in the United States","author":"Garnett M.","year":"2026"},{"key":"e_1_2_11_4_1","unstructured":"U.S. Department of Health and Human Services.Organ procurement and transplantation network. National data. 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