{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:35:36Z","timestamp":1773372936042,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction: The brain\u2010derived neurotrophic factor (BDNF) Val66Met variant and HMG\u2010COA reductase inhibitors (statins) have been implicated in insulin resistance with a possible increased risk of diabetes. We sought to determine the effect of the BDNF Met variant and statin medication use on insulin resistance in schizophrenia and bipolar disorder using the homeostasis model assessment of insulin resistance (HOMA\u2010IR).<\/jats:p><jats:p>Methods: A cross\u2010sectional design was used and patients with diabetes or on any medications affecting glucose regulation were \u2010excluded. Associations between insulin resistance and genotype were then analyzed by ANOVA and regression analysis. Subjects were grouped by BDNF genotype as well as presence of statin.<\/jats:p><jats:p>Results: Two hundred fifty\u2010two subjects with a mean age of 44 years were included. The group was 53% male and 41% had a diagnosis of bipolar disorder; 78% and 19% were receiving atypical antipsychotics (AAPs) and statin medications, respectively. Analysis showed schizophrenia subjects with the BDNF met allele as well as schizophrenia subjects with both the BDNF met allele and were receiving a statin had significantly higher HOMA\u2010IR values compared to the other groups (<jats:italic>p<\/jats:italic>= 0.046 and <jats:italic>p<\/jats:italic>= 0.016, respectively).<\/jats:p><jats:p>Conclusions: Our results suggest that in the metabolically high\u2010risk population of schizophrenia the BDNF met allele alone and in combination with statin medications is associated with higher insulin resistance values. This was not seen in the bipolar population. Further validation of these associations remains necessary. Clin Trans Sci 2012; Volume 5: 486\u2013490<\/jats:p>","DOI":"10.1111\/cts.12001","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T16:29:20Z","timestamp":1351787360000},"page":"486-490","source":"Crossref","is-referenced-by-count":7,"title":["The Influence of the Brain\u2010Derived Neurotropic Factor Val66Met \u2010Genotype and HMG\u2010CoA Reductase Inhibitors on Insulin Resistance in the Schizophrenia and Bipolar 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