{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:35:14Z","timestamp":1783175714096,"version":"3.54.6"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T00:00:00Z","timestamp":1366329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sexual minority girls (SMGs) are four times more likely to engage in substance use than are heterosexual girls. A better understanding of the explanatory mechanisms of this disparity is needed to inform prevention and intervention programs. The goal of this study was to conduct a preliminary test of a \u201cstress\u2010negative affect\u201d pathway by examining gay\u2010related victimization and depression as mediators of substance use among SMGs. Adolescent girls (<jats:italic>N<\/jats:italic> = 156, 41% SMGs) were recruited from two urban adolescent medicine clinics to participate in an NIH\u2010funded study of adolescent substance use. The average age was 17.0 years old and 57% were nonwhite. Mediation analyses were conducted in a multiple regression framework using SPSS and a mediation macro utilizing bias\u2010corrected bootstrapping. Four models were estimated to test mediated pathways from sexual orientation to gay\u2010related victimization (Mediator 1), to depression symptoms (Mediator 2), and then to each of four substance use variables: cigarettes, marijuana, alcohol, and heavy alcohol use. Significant mediated pathways (mediation tests with 95% CIs) were found for cigarette, alcohol and heavy alcohol use outcome variables. Results provide preliminary support for the minority stress hypothesis and the stress\u2010negative affect pathway, and may inform the development of future prevention and intervention programs.<\/jats:p>","DOI":"10.1111\/cts.12052","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T18:58:41Z","timestamp":1366397921000},"page":"321-322","source":"Crossref","is-referenced-by-count":30,"title":["Cross\u2010Sectional Evidence for a Stress\u2010Negative Affect Pathway to Substance Use among Sexual Minority Girls"],"prefix":"10.1111","volume":"6","author":[{"given":"Michael P.","family":"Marshal","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Pediatrics School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena J.","family":"Chisolm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina S.","family":"Sucato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Friedman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Department of Behavioral and Community Health Sciences Graduate School of Public Health  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02149.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.129.5.674"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2009.190009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-005-7264-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-009-9397-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0024519"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_9_1","unstructured":"HayesAF.2012.PROCESS: A versatile computational tool for observed variable mediation moderation and conditional process modeling [White paper]. 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