{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:00:06Z","timestamp":1782979206830,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Homocysteine metabolism is altered in children with idiopathic nephrotic syndrome. Hyperhomocysteinemia is a risk factor of early atherosclerosis and glomerulosclerosis and may occur at time of first occurrence of idiopathic nephrotic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty children with first episode of idiopathic nephrotic syndrome (FENS) aged 1\u201316 years along with 30 age\u2010 and sex\u2010matched healthy controls were enrolled in this study. Homocysteine and cysteine were measured with HPLC; vitamin B<jats:sub>12<\/jats:sub> and folic acid were measured with electro\u2010chemilumiscence immunoassay. Primary outcome measure was plasma homocysteine level in children with FENS and in controls. Secondary outcome measures were (1) plasma and urine homocysteine and cysteine levels in children with FENS at 12 weeks and 1 year (remission) and (2) plasma and urine levels of vitamin B<jats:sub>12<\/jats:sub> and folic acid in children with FENS, at 12 weeks and 1 year (remission).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma homocysteine and cysteine levels were comparable to controls in children with FENS, at 12 weeks and 1\u2010year remission. Plasma levels of vitamin B12 and folic acid were significantly decreased compared to controls in FENS due to increased urinary excretion, which normalize during remission at 12 weeks and 1 year. Urinary homocysteine and cysteine levels were significantly raised in FENS compared to controls and continued to be raised even at 12\u2010week and 1\u2010year remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Homocysteine metabolism is deranged in children with FENS. Renal effects of long\u2010term raised urinary homocysteine levels need to be studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cts.12145","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T17:29:58Z","timestamp":1390498198000},"page":"132-136","source":"Crossref","is-referenced-by-count":5,"title":["Homocysteine Metabolism in Children with Idiopathic Nephrotic Syndrome"],"prefix":"10.1111","volume":"7","author":[{"given":"Mohan","family":"Kundal","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Postgraduate Institute of Medical Education and Research associated Dr. Ram Manohar Lohia Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Saha","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.K.","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Pathology GB Pant Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Biostatistics AIIMS  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trayambak","family":"Basak","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay Singh","family":"Tanwar","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Sengupta","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Pathology GB Pant Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Dutt","family":"Upadhayay","sequence":"additional","affiliation":[{"name":"Department of Biostatistics AIIMS  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Bhatt","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14184-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004679900253"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614438"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1460-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614438"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1029-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy02t2.102992"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.12.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090000093"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.1.45"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.8.1720"},{"key":"e_1_2_8_13_1","first-page":"203","article-title":"Indian Academy of Pediatrics. 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