{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:36:45Z","timestamp":1791005805979,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Carlyle Fraser Foundation"},{"name":"Emory University Pilot Research Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asthma is a chronic airway inflammatory disease with episodic symptoms of wheezing, chest tightness, cough, and shortness of breath. High ambient ozone levels have been associated with increased airway inflammation and asthma morbidity in prior studies. Mechanisms underlying individual susceptibility to asthma exacerbations from poor air quality are not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>As part of a panel observational study, we hypothesized that systemic antioxidant ability and antioxidant status may be associated with more stable asthma during high ozone season. Methods: A cross sectional study was performed to evaluate the antioxidant profile in systemic circulation and its associations with clinical parameters in asthmatics and healthy controls during three summers in Atlanta, Georgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this panel of individuals with and without asthma, we found that although systemic glutathione levels were not different between the groups, serum albumin was significantly lower in the asthmatic group. Albumin also significantly correlated with lung function (%FEV1) and asthma quality of life scores. In a subgroup tested, plasma reduced glutathione (GSH) levels were associated with worse airways obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antioxidants GSH and albumin may have a role in maintaining lung function and asthma stability during times of poor ambient air quality. Clin Trans Sci 2014; Volume #: 1\u20135<\/jats:p><\/jats:sec>","DOI":"10.1111\/cts.12152","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T12:13:12Z","timestamp":1398082392000},"page":"314-318","source":"Crossref","is-referenced-by-count":13,"title":["Systemic Antioxidants and Lung Function in Asthmatics during High Ozone Season: A Closer Look at Albumin, Glutathione, and Associations with Lung Function"],"prefix":"10.1111","volume":"7","author":[{"given":"Sumita B.","family":"Khatri","sequence":"first","affiliation":[{"name":"Department of Medicine Respiratory Institute Cleveland Clinic Cleveland Clinic Lerner College of Medicine\u2010CWRU  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Peabody","sequence":"additional","affiliation":[{"name":"Emory Healthcare  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandrea","family":"Burwell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LouAnnE S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"NHLBI.Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma Full Report 2007.2007."},{"key":"e_1_2_7_3_1","unstructured":"NHLBI\/WHO.NHLBI\/WHO Workshop Report. 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