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The primary objective of this study is to characterize the previously unknown lipid profile of sinonasal mucosa from patients with chronic rhinosinusitis (CRS) and from controls. Sinus mucosa samples were analyzed from 9 CRS patients with concomitant nasal polyps, 11 CRS patients without polyps, and 12 controls. Ten lone polyp samples were also analyzed. Samples were subjected to a modified Bligh\/Dyer lipid extraction, then high performance thin layer chromatography (HPTLC), combined gas chromatography\/electron impact\u2010mass spectrometry (GC\/EI\u2010MS), and flow\u2010injection\/electrospray ionization\u2010tandem mass spectrometry (FI\/ESI\u2010MS\/MS). Data was analyzed for identification and profiling of major components. HPTLC revealed an array of species reflecting the lipid complexity of the samples. GC\/EI\u2010MS revealed cholesterol and several fatty acids. FI\/ESI\u2010MSMS revealed numerous lipid species, namely a host of phosphatidylcholines, phosphatidylethanolamines, ceramides and cholesteryl esters, but no detectable amounts of phosphatidyinositols or sulfated lipids. These results are a first step to uncover unique molecular biomarkers in CRS.<\/jats:p>","DOI":"10.1111\/cts.12256","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T13:09:57Z","timestamp":1421327397000},"page":"107-115","source":"Crossref","is-referenced-by-count":13,"title":["Lipidomic Profiling of Sinus Mucosa from Patients with Chronic Rhinosinusitis"],"prefix":"10.1111","volume":"8","author":[{"given":"Farbod","family":"Fazlollahi","sequence":"first","affiliation":[{"name":"Pasarow Mass Spectrometry Laboratory, NPI\u2010Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California  Los Angeles California USA"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, UCLA Health System  Los Angeles California USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California  Los Angeles California 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