{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:59:38Z","timestamp":1789729178064,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["dnr 521-2012-5706"],"award-info":[{"award-number":["dnr 521-2012-5706"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Integrative Regenerative Medicine Centre, Link\u00f6ping, Sweden"},{"name":"Swedish Institute fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high\u2010risk patients, and therefore, merits further testing in a clinical trial.<\/jats:p>","DOI":"10.1111\/cts.12293","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T07:34:47Z","timestamp":1432193687000},"page":"558-562","source":"Crossref","is-referenced-by-count":86,"title":["Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High\u2010Risk Patients"],"prefix":"10.1111","volume":"8","author":[{"given":"Oleksiy","family":"Buznyk","sequence":"first","affiliation":[{"name":"Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine  Odessa Ukraine"},{"name":"Integrative Regenerative Medicine Center Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Pasyechnikova","sequence":"additional","affiliation":[{"name":"Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine  Odessa Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mirazul","family":"Islam","sequence":"additional","affiliation":[{"name":"Integrative Regenerative Medicine Center Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Neurosciences Swedish Medical Nanoscience Center  Karolinska Institutet, Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Iakymenko","sequence":"additional","affiliation":[{"name":"Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine  Odessa Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Fagerholm","sequence":"additional","affiliation":[{"name":"Integrative Regenerative Medicine Center Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Griffith","sequence":"additional","affiliation":[{"name":"Integrative Regenerative Medicine Center Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Neurosciences Swedish Medical Nanoscience Center  Karolinska Institutet, Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"A brief review of Boston type\u20101 and osteo\u2010odontokeratoprostheses","author":"Avadhanam VS","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60437-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00024-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301947"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000225"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.01.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0064"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000357"},{"key":"e_1_2_7_11_1","unstructured":"PasyechnikovaNV DrozhzhynaGI OstashevskiyVL GaydamakaTB. 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