{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:19:22Z","timestamp":1771017562069,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UAMS College of Pharmacy Start-Up Funds"},{"name":"UAMS College of Pharmacy Voldeng Fellowships"},{"name":"National Institutes of Health Awards","award":["UL1TR000039"],"award-info":[{"award-number":["UL1TR000039"]}]},{"name":"National Institutes of Health Awards","award":["KL2TR000063"],"award-info":[{"award-number":["KL2TR000063"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A hallmark of cystic fibrosis (CF) lung disease is neutrophilic airway inflammation. Elevated neutrophil counts have been associated with decreased forced expiratory volume in 1 second and poor clinical measures in patients with CF. Interleukin 8 (IL\u20108), epithelial neutrophil activating protein 78 (ENA\u201078), tumor necrosis factor alpha (TNF\u2010\u03b1), granulocyte macrophage colony\u2010stimulating factor (GM\u2010CSF), and granulocyte colony\u2010stimulating factor (G\u2010CSF) contribute to neutrophil activation and disease pathogenesis in the airways of patients with CF. Drugs that modify the production of these chemokines in the airways could potentially benefit CF patients. Thus, we determined the effects of fenofibrate on their production in cell populations obtained from the airways. Human small airway epithelial cells and CF bronchial epithelial cells were treated with IL\u20101\u03b2 to induce inflammation. We cotreated the cells with fenofibrate at concentrations ranging from 10 to 50 \u03bcM to determine if this drug could attenuate the inflammation. IL\u20108, ENA\u201078, TNF\u2010\u03b1, GM\u2010CSF, and G\u2010CSF production were measured from the cell culture supernates by ELISA. ANOVA statistical testing was conducted using SPSS 17.0. IL\u20101\u03b2 increased the production of each of the chemokines by several fold. Fenofibrate reduced IL\u20101\u03b2 induced production of each of these neutrophilic chemokines at the concentrations used. IL\u20101\u03b2 increases the production of neutrophilic chemokines in airway epithelial cells. Cotreatment with fenofibrate blunts these processes. Fenofibrate should be explored as a therapeutic option to modulate the abundant neutrophilic inflammation observed in CF.<\/jats:p>","DOI":"10.1111\/cts.12310","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T14:54:51Z","timestamp":1439218491000},"page":"696-701","source":"Crossref","is-referenced-by-count":13,"title":["Fenofibrate Attenuates Neutrophilic Inflammation in Airway Epithelia: Potential Drug Repurposing for Cystic Fibrosis"],"prefix":"10.1111","volume":"8","author":[{"given":"Amanda J.","family":"Stolarz","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Arkansas for Medical, Sciences College of Pharmacy  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan A.","family":"Farris","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Arkansas for Medical, Sciences College of Pharmacy  Little Rock Arkansas 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