{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:43Z","timestamp":1790268763497,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["R01 MH082784"],"award-info":[{"award-number":["R01 MH082784"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH-NCCR, GCRC","award":["UL1RR024986"],"award-info":[{"award-number":["UL1RR024986"]}]},{"name":"NIH-NCCR, GCRC","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}]},{"name":"Michigan Diabetes Research and Training Center","award":["P30DK020572"],"award-info":[{"award-number":["P30DK020572"]}]},{"name":"Michigan Diabetes Research and Training Center","award":["P30DK092926"],"award-info":[{"award-number":["P30DK092926"]}]},{"name":"Health Organization (WCHO, Ann Arbor, Michigan)"},{"DOI":"10.13039\/100000874","name":"The Brain and Behavior Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Michigan Institute of Clinical and Health Research (MICHR)","award":["UL1RR024986"],"award-info":[{"award-number":["UL1RR024986"]}]},{"name":"Prechter Longitudinal Study of Bipolar Disorder"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Second generation antipsychotic (SGA) use in bipolar disorder is common and has proven effective in short\u2010term trials. There continues to be a lack of understanding of the mechanisms underlying many of their positive and negative effects in bipolar disorder. This study aimed to describe the metabolite profiles of bipolar subjects treated with SGAs by comparing to metabolite profiles of bipolar subjects treated with lithium, and schizophrenia subjects treated with SGAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional, fasting untargeted serum metabolomic profiling was conducted in 82 subjects diagnosed with bipolar I disorder (<jats:italic>n<\/jats:italic> = 30 on SGAs and <jats:italic>n<\/jats:italic> = 32 on lithium) or schizophrenia (<jats:italic>n<\/jats:italic> = 20). Metabolomic profiles of bipolar subjects treated with SGAs were compared to bipolar subjects treated with lithium and schizophrenia subjects treated with SGAs using multivariate methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Partial lease square discriminant analysis (PLS\u2010DA) plots showed separation between bipolar subjects treated with SGAs, bipolar subjects treated with lithium, or schizophrenia subjects treated with SGAs. Top influential metabolite features were associated with several pathways including that of polyunsaturated fatty acids, pyruvate, glucose, and branched chain amino acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings from this study require further validation in pre\u2010 and posttreated bipolar and schizophrenia subjects, but suggest that the pharmacometabolome may be diagnosis specific.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cts.12324","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T03:35:21Z","timestamp":1440732921000},"page":"432-440","source":"Crossref","is-referenced-by-count":35,"title":["An Untargeted Metabolomics Analysis of Antipsychotic Use in Bipolar Disorder"],"prefix":"10.1111","volume":"8","author":[{"given":"Kyle J.","family":"Burghardt","sequence":"first","affiliation":[{"name":"Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"Wiese","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki L.","family":"Ellingrod","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"},{"name":"College of Pharmacy University of Michigan  Ann Arbor Michigan 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