{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:17:51Z","timestamp":1769123871827,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NCRR Colorado Clinical and Translational Sciences Institute","award":["ULI RR025780"],"award-info":[{"award-number":["ULI RR025780"]}]},{"name":"CDC-NIOSH Mountains and Plans Education and Research Center","award":["1T42OH009229-01"],"award-info":[{"award-number":["1T42OH009229-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>An epoxy resin worker developed hypersensitivity pneumonitis requiring lung transplantation and had an abnormal blood lymphocyte proliferation test (LPT) to an epoxy hardener. We assessed the prevalence of symptoms, abnormal spirometry, and abnormal epoxy resin LPT results in epoxy resin workers compared to unexposed workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants completed questionnaires and underwent spirometry. We collected blood for epoxy resin LPT and calculated stimulation indices for five epoxy resin products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compared 38 exposed to 32 unexposed workers. Higher exposed workers were more likely to report cough (OR 10.86, [1.23\u2010infinity], <jats:italic>p<\/jats:italic> = 0.030) or wheeze (OR 4.44, [1.00\u201022.25], <jats:italic>p<\/jats:italic> = 0.049) than unexposed workers, even controlling for smoking. Higher exposed workers were more likely to have abnormal FEV1 than unexposed workers (OR 10.51, [0.86\u2010589.9], p = 0.071), although not statistically significant when adjusted for smoking. There were no differences in proportion of abnormal epoxy resin system LPTs between exposed and unexposed workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, workers exposed to epoxy resin system chemicals were more likely to report respiratory symptoms and have abnormal FEV1 than unexposed workers. Use of epoxy resin LPT was not helpful as a biomarker of exposure and sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cts.12341","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T10:07:07Z","timestamp":1447150027000},"page":"722-728","source":"Crossref","is-referenced-by-count":5,"title":["Cross\u2010Sectional Study of Respiratory Symptoms, Spirometry, and Immunologic Sensitivity in Epoxy Resin Workers"],"prefix":"10.1111","volume":"8","author":[{"given":"Stella E.","family":"Hines","sequence":"first","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Department of Medicine, The University of Maryland  Baltimore Maryland USA"},{"name":"Division of Pulmonary and Critical Care, Department of Medicine, The University of Maryland  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Barker","sequence":"additional","affiliation":[{"name":"National Jewish Health, Division of Environmental and Occupational Health Sciences, Department of Medicine  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Robinson","sequence":"additional","affiliation":[{"name":"National Jewish Health, Division of Environmental and Occupational Health Sciences, Department of Medicine  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Knight","sequence":"additional","affiliation":[{"name":"National Jewish Health Division of Pathology, Department of Medicine  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Gaitens","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Department of Medicine, The University of Maryland  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sills","sequence":"additional","affiliation":[{"name":"National Jewish Health Division of Pathology, Department of Medicine  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirby","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Environmental &amp; Occupational Health Colorado School of Public Health  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile S.","family":"Rose","sequence":"additional","affiliation":[{"name":"National Jewish Health, Division of Environmental and Occupational Health Sciences, Department of Medicine  Denver Colorado USA"},{"name":"Department of Environmental &amp; Occupational Health Colorado School of Public Health  Denver Colorado USA"},{"name":"Division of Pulmonary Sciences &amp; Critical Care Medicine Department of Medicine, School of Medicine, The University of Colorado\u2010Denver  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,10]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"743","article-title":"Epoxy resins","volume":"14","author":"Bray PG.","year":"1999","journal-title":"Occup Med"},{"key":"e_1_2_7_3_1","unstructured":"Global Industry AnalystsI.Global Epoxy Resins Market to Reach 3.03 Million Tons by 2017 According to a New Report by Global Industry Analysts Inc.www.prweb.com\/releases\/epoxy_ resins\/paints_coatings_laminates\/prweb8343600.htm. 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