{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:49:19Z","timestamp":1790048959327,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401750"],"award-info":[{"award-number":["81401750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Phototherapy has been widely used in treating neonatal jaundice, but detailed metabonomic profiles of\u00a0neonatal jaundice patients and response to phototherapy have not been characterized. Our aim was to depict the serum metabolic characteristics of neonatal jaundice patients relative to controls and changes in response to phototherapy. A <jats:sup>1<\/jats:sup>H nuclear magnetic resonance (NMR)\u2010based metabonomic approach was employed to study the metabolic profiling of serum from healthy infants (<jats:italic>n<\/jats:italic> = 25) and from infants with neonatal jaundice (<jats:italic>n<\/jats:italic> = 30) pre\u2010\u00a0and\u00a0postphototherapy. The acquired data were processed by multivariate principal component analysis (PCA) and orthogonal partial least\u2010squares\u2010discriminant analysis (OPLS\u2010DA). The PLS\u2010DA and OPLS\u2010DA model identified nine metabolites capable of distinguishing patients from controls. In addition, 28 metabolites such as \u03b2\u2010glucose, \u03b1\u2010glucose, valine, and pyruvate changed in response to phototherapy. This study offers useful information on metabolic disorders in neonatal jaundice patients and the effects of phototherapy on lipids, amino acid, and energy metabolism.<\/jats:p>","DOI":"10.1111\/cts.12401","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T06:21:41Z","timestamp":1466058101000},"page":"216-220","source":"Crossref","is-referenced-by-count":10,"title":["A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy"],"prefix":"10.1111","volume":"9","author":[{"given":"A","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Laboratory Nanshan Affiliated Hospital of Guangdong Medical College  Shenzhen Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Medical school Shenzhen University  Guangdong P.R. 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