{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:41Z","timestamp":1787014061191,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C0065"],"award-info":[{"award-number":["HI14C0065"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C2770"],"award-info":[{"award-number":["HI14C2770"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    To explore potential biomarkers for amoxicillin\/clavulanate\u2010induced liver injury (AC\u2010DILI), we conducted a clinical trial in 32 healthy subjects based on multi\u2010omics approaches. Every subject was administered amoxicillin\/clavulanate for 14 days. The liver\u2010specific microRNA\u2010122 (miR\u2010122) level increased prior to and correlated well with the observed alanine aminotransferase (ALT) level increase. This result indicates its potential as a sensitive early marker for AC\u2010DILI. We also identified urinary metabolites, such as azelaic acid and 7\u2010methylxanthine, with levels that significantly differed among the groups classified by ALT elevation level on day 8 after drug administration (\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05). Lymphocyte proliferation in response to the drug was also observed. These findings demonstrate sequential changes in the process of AC\u2010DILI, including metabolic changes, increased miR\u2010122 level, increased liver enzyme activity, and enhanced lymphocyte proliferation after drug administration. In conclusion, this study provides potential biomarkers for AC\u2010DILI based on currently known mechanisms using comprehensive multi\u2010omics approaches.\n                  <\/jats:p>","DOI":"10.1111\/cts.12425","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:09:10Z","timestamp":1477526950000},"page":"163-171","source":"Crossref","is-referenced-by-count":24,"title":["Exploration of Biomarkers for Amoxicillin\/Clavulanate\u2010Induced Liver Injury: Multi\u2010Omics Approaches"],"prefix":"10.1111","volume":"10","author":[{"given":"J","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SC","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KH","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JY","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics CHA University School of Medicine and CHA Bundang Medical Center  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SH","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SH","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JY","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HS","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Clinical Immunology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SH","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Clinical Immunology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IJ","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2155"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.027"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23505"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23358"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.379"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500458"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12211"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.02.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24538"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25873"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/24\/40\/405102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2013.09.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.101"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.151"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.07.021"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.240"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904489106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488610791698307"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.08.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068111"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27912"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.22"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2014.904201"},{"key":"e_1_2_10_27_1","first-page":"99","article-title":"Metabonomics for discovering biomarkers of hepatotoxicity and nephrotoxicity","volume":"67","author":"Zhang A.","year":"2012","journal-title":"Pharmazie"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22370"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01107.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.10.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240533"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)40745-X"},{"key":"e_1_2_10_33_1","first-page":"97","article-title":"Induction of oxidative stress in antitubercular drug\u2010induced hepatotoxicity","volume":"20","author":"Chowdhury A.","year":"2001","journal-title":"Indian J. Gastroenterol."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00547.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019055108"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2210"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003694"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21324"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.131797"},{"key":"e_1_2_10_40_1","first-page":"2223","article-title":"Special considerations in interpreting liver function tests","volume":"59","author":"Johnston D.E.","year":"1999","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_10_41_1","first-page":"1105","article-title":"Mildly elevated liver transaminase levels in the asymptomatic patient","volume":"71","author":"Giboney P.T.","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(96)04832-X"},{"key":"e_1_2_10_43_1","first-page":"67","article-title":"Lymphocyte transformation test for the evaluation of adverse effects of antituberculous drugs","volume":"4","author":"Schreiber J.","year":"1999","journal-title":"Eur. J. Med. Res"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcts.12425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcts.12425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:55:09Z","timestamp":1696348509000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cts.12425"],"URL":"https:\/\/doi.org\/10.1111\/cts.12425","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]}}}