{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:21:57Z","timestamp":1784208117857,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH K23 GM102678"],"award-info":[{"award-number":["NIH K23 GM102678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 GM074518"],"award-info":[{"award-number":["U01 GM074518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL105198"],"award-info":[{"award-number":["U01 HL105198"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Genetic variation in the platelet endothelial aggregation receptor 1 (<jats:italic>PEAR1<\/jats:italic>) gene, most notably rs12041331, is implicated in altered on\u2010aspirin platelet aggregation and increased cardiovascular event risk. We prospectively tested the effects of aspirin administration at commonly prescribed doses (81, 162, and 324\u00a0mg\/day) on agonist\u2010induced platelet aggregation by rs12041331 genotype in 67 healthy individuals. Prior to aspirin administration, rs12041331 minor allele carriers had significantly reduced adenosine diphosphate (ADP)\u2010induced platelet aggregation compared with noncarriers (<jats:italic>P<\/jats:italic> = 0.03) but was not associated with other platelet pathways. In contrast, rs12041331 was significantly associated with on\u2010aspirin platelet aggregation when collagen and epinephrine were used to stimulate platelet aggregation (<jats:italic>P<\/jats:italic> &lt; 0.05 for all associations), but not ADP. The influence of <jats:italic>PEAR1<\/jats:italic> rs12041331 on platelet aggregation is pathway\u2010specific and is altered by aspirin at therapeutic doses, but not in a dose\u2010dependent manner. Additional studies are needed to determine the impact of <jats:italic>PEAR1<\/jats:italic> on cardiovascular events in aspirin\u2010treated patients.<\/jats:p>","DOI":"10.1111\/cts.12438","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T13:58:34Z","timestamp":1484143114000},"page":"102-109","source":"Crossref","is-referenced-by-count":26,"title":["Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin\u2010Dependent Effects on Platelet Aggregation Pathways"],"prefix":"10.1111","volume":"10","author":[{"given":"JD","family":"Backman","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition, and Program for Personalized and Genomic Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LM","family":"Yerges\u2010Armstrong","sequence":"additional","affiliation":[{"name":"Division 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