{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:26:09Z","timestamp":1740151569830,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We sought to assess whether a high\u2010profile publication that demonstrated serious clinical consequences of specific drug\u2010drug interactions (DDIs) reduced the concomitant use of those drugs. We conducted a quasi\u2010experimental study using 2000\u20132008 prescription claims from a commercial health insurer to examine trends in the dispensing of the interacting drug pairs (angiotensin\u2010converting enzyme inhibitors[ACEI] + potassium\u2010sparing diuretic, digoxin + clarithromycin, and glyburide + cotrimoxazole) and control drug pairs previously reported in a top\u2010tier general medicine journal. We examined prepublication and postpublication dispensing trends using Poisson regression. ACEI + potassium\u2010sparing diuretic use did not differ postpublication vs. prepublication (<jats:italic>P<\/jats:italic> = 0.11). Digoxin + clarithromycin use decreased minimally postpublication vs. prepublication (relative rate = 0.9996: 95% confidence interval [CI] = 0.9993\u20130.9998). Glyburide + cotrimoxazole use increased minimally postpublication vs. prepublication (relative rate = 1.0220; 95% CI = 1.0187\u20131.0254). Therefore, the high\u2010profile DDI publication had minimal to no measurable effect in reducing the concomitant use of the interacting drugs studied. We believe that better strategies are needed to translate knowledge about DDIs into clinical practice.<\/jats:p>","DOI":"10.1111\/cts.12494","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T16:22:36Z","timestamp":1501258956000},"page":"426-430","source":"Crossref","is-referenced-by-count":0,"title":["Lost in Translation: No Effect of a High\u2010Profile Publication on the Concomitant Use of Interacting Drugs"],"prefix":"10.1111","volume":"10","author":[{"given":"Emily K.","family":"Acton","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital of the University of Pennsylvania  Philadelphia PA USA"},{"name":"Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Center for Pharmacoepidemiology Research and Training Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren B.","family":"Bilker","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Center for Pharmacoepidemiology Research and Training Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobha","family":"Phansalkar","sequence":"additional","affiliation":[{"name":"Department of General Medicine and Primary Care Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Center for Pharmacoepidemiology Research and Training Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA 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