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We hypothesized that transfusion of even freshly\u2010stored blood used in pediatric heart surgery would reduce SNO\u2010Hb levels and worsen outcome. In a retrospective review (<jats:italic>n =<\/jats:italic> 29), the percent of estimated blood volume (% eBV) replaced by transfusion directly correlated with ventilator time and inversely correlated with kidney function; similar results were obtained in a prospective arm (<jats:italic>n =<\/jats:italic> 20). In addition, an inverse association was identified between SNO\u2010Hb and postoperative increase in Hb (\u2206Hb), reflecting the amount of blood retained by the patient. Both SNO\u2010Hb and \u2206Hb correlated with the probability of kidney dysfunction and oxygenation\u2010related complications. Further, regression analysis identified SNO\u2010Hb as an inverse predictor of outcome. The findings suggest that SNO\u2010Hb and \u2206Hb are prognostic biomarkers following pediatric cardiopulmonary bypass, and that maintenance of red blood cell\u2010derived NO bioactivity might confer therapeutic benefit.<\/jats:p>","DOI":"10.1111\/cts.12530","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T22:53:09Z","timestamp":1513119189000},"page":"237-243","source":"Crossref","is-referenced-by-count":7,"title":["S\u2010Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery"],"prefix":"10.1111","volume":"11","author":[{"given":"Faisal","family":"Matto","sequence":"first","affiliation":[{"name":"Institute for Transformative Molecular Medicine School of Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Kouretas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery Rainbow Babies &amp; Children's Hospital, University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery Rainbow Babies &amp; Children's Hospital, University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Ostrowsky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery Rainbow Babies &amp; Children's Hospital, University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Cina","sequence":"additional","affiliation":[{"name":"Institute for Transformative Molecular Medicine School of Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas T.","family":"Hess","sequence":"additional","affiliation":[{"name":"Institute for Transformative Molecular Medicine School of Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan S.","family":"Stamler","sequence":"additional","affiliation":[{"name":"Institute for Transformative Molecular Medicine School of Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"},{"name":"Harrington Discovery Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Institute for Transformative Molecular Medicine School of Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Anesthesia &amp; Perioperative Medicine, University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.07.037"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182745472"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03097.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1962.202.1.21"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.08.002"},{"key":"e_1_2_10_8_1","article-title":"Hemoglobin \u03b2cys93 is essential for cardiovascular function and integrated response to hypoxia","author":"Zhang R.","year":"2015","journal-title":"Proc. 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