{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:07:38Z","timestamp":1790842058356,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000092","name":"Ontario Genomics Institute","doi-asserted-by":"publisher","award":["OGI\u2010049"],"award-info":[{"award-number":["OGI\u2010049"]}],"id":[{"id":"10.13039\/501100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000233","name":"Genome British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Duchenne muscular dystrophy is a recessive X\u2010linked disease characterized by progressive muscle wasting; cardiac or respiratory failure causes death in most patients by the third decade.\u00a0 The disease is caused by mutations in the dystrophin gene that lead to a loss of functional dystrophin protein. Although there are currently few treatments for Duchenne muscular dystrophy, previous reports have shown that upregulating the dystrophin paralog utrophin in Duchenne muscular dystrophy mouse models is a promising therapeutic strategy. We conducted <jats:italic>in silico<\/jats:italic> mining of the Connectivity Map database for utrophin\u2010inducing agents, identifying the p38\u2010activating antibiotic anisomycin. Treatments of C2C12, undifferentiated murine myoblasts, and <jats:italic>mdx<\/jats:italic> primary myoblasts with anisomycin conferred increases in utrophin protein levels through p38 pathway activation.\u00a0 Anisomycin also induced utrophin protein levels in the diaphragm of <jats:italic>mdx<\/jats:italic> mice.\u00a0 Our study shows that repositioning small molecules such as anisomycin may prove to have Duchenne muscular dystrophy clinical utility<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/cts.12562","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T11:00:19Z","timestamp":1528369219000},"page":"506-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anisomycin Activates Utrophin Upregulation Through a p38 Signaling Pathway"],"prefix":"10.1111","volume":"11","author":[{"given":"Jeremiah","family":"Hadwen","sequence":"first","affiliation":[{"name":"University of Ottawa  Ottawa Canada"},{"name":"Apoptosis Research Center CHEO Research Institute  CHEO Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz","family":"Farooq","sequence":"additional","affiliation":[{"name":"Apoptosis Research Center CHEO Research Institute  CHEO Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Witherspoon","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Canada"},{"name":"Apoptosis Research Center CHEO Research Institute  CHEO Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schock","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Canada"},{"name":"Apoptosis Research Center CHEO Research Institute  CHEO Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Mongeon","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Canada"},{"name":"Apoptosis Research Center CHEO Research Institute  CHEO Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Canada"},{"name":"Apoptosis Research Center CHEO Research Institute  CHEO Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2044"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90504-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00281063"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8089-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000126574.61061.25"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(91)90001-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100009926"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200002)29:2<141::AID-PPUL9>3.0.CO;2-Y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00833.2013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7353com"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/352536a0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.02.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1996.tb00781.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv154"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057112465648"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150818"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24692"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132939"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2006.00420.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt165"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-015-9406-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.01.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-017-0018-3"},{"key":"e_1_2_10_25_1","first-page":"114","article-title":"Anisomycin in intestinal amebiasis; study of 30 clinical cases","volume":"21","author":"Gonzalez Constandse R.","year":"1956","journal-title":"Prensa. 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