{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:28:53Z","timestamp":1789964933032,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Cosmetics Europe"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real\u2010life use conditions. A simple roll\u2010on formulation containing an extremely rare isotope of aluminum (<jats:sup>26<\/jats:sup>Al) chlorohydrate (<jats:styled-content style=\"fixed-case\">ACH<\/jats:styled-content>) was prepared to commercial specifications. A <jats:sup>26<\/jats:sup>Al radio\u2010microtracer was used to distinguish dosed aluminum from natural background, using accelerated mass spectroscopy. The <jats:sup>26<\/jats:sup>Al citrate was administered intravenously (i.v.) to estimate fraction absorbed (F<jats:sub>abs<\/jats:sub>) following topical delivery. In blood samples after i.v. administration, <jats:sup>26<\/jats:sup>Al was readily detected (mean area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>)\u00a0=\u00a01,273\u00a0\u00b1\u00a0466\u00a0hours\u00d7fg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). Conversely, all blood samples following topical application were below the lower limit of quantitation (<jats:styled-content style=\"fixed-case\">LLOQ<\/jats:styled-content>; 0.12\u00a0fg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>), except two samples (0.13 and 0.14\u00a0fg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>); a maximal <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> was based on <jats:styled-content style=\"fixed-case\">LLOQ<\/jats:styled-content>s. The aluminum was above the <jats:styled-content style=\"fixed-case\">LLOQ<\/jats:styled-content> (61 ag\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) in 31% of urine samples. From the urinary excretion data, a conservative estimated range for dermal F<jats:sub>abs<\/jats:sub> of 0.002\u20130.06% was calculated, with a mean estimate of 0.0094%.<\/jats:p>","DOI":"10.1111\/cts.12579","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T15:35:13Z","timestamp":1532705713000},"page":"573-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a <sup>26<\/sup>Al Microtracer Approach"],"prefix":"10.1111","volume":"11","author":[{"given":"Rianne","family":"de Ligt","sequence":"first","affiliation":[{"name":"TNO  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"van Duijn","sequence":"additional","affiliation":[{"name":"TNO  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Grossouw","sequence":"additional","affiliation":[{"name":"TNO  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieto","family":"Bosgra","sequence":"additional","affiliation":[{"name":"BioMarin Nederland B.V.  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus","family":"Burggraaf","sequence":"additional","affiliation":[{"name":"Center for Human Drug Research  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Windhorst","sequence":"additional","affiliation":[{"name":"VU Medical Center Department of Radiology and Nuclear Medicine  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre A.M.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Center for Human Drug Research  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit A.","family":"van der Luijt","sequence":"additional","affiliation":[{"name":"Center for Human Drug Research  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Alexander\u2010White","sequence":"additional","affiliation":[{"name":"MKTox  Milton Keynes UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter H.J.","family":"Vaes","sequence":"additional","affiliation":[{"name":"TNO  Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2001.01028.x"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.05.008"},{"key":"e_1_2_10_3_1","unstructured":"SCCS.Opinion on the safety of aluminium in cosmetic products.; 2014. Contract No.: SCCS\/1525\/14 Revision of 18 June 2014."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(00)00118-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2003.09.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/15.2.66"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2007.01.035"},{"key":"e_1_2_10_8_1","unstructured":"VKM Norwegian scientific Committee for Food Safety Risk assessment of the exposure to aluminium through food and the use of cosmetic products in the Norwegian population. 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