{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:21:44Z","timestamp":1787163704065,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T00:00:00Z","timestamp":1538179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008478","name":"Instituto Nacional del C\u00e1ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925, a new chemical entity, acts as a co\u2010agonist to glutamate at the N\u2010methyl\u2010D\u2010aspartate receptor (\n                    <jats:styled-content style=\"fixed-case\">NMDAR<\/jats:styled-content>\n                    ). At low concentrations of endogenous agonists (glycine\/D\u2010serine),\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925 partially activates\n                    <jats:styled-content style=\"fixed-case\">NMDAR<\/jats:styled-content>\n                    s, modulating neural pathways relevant for chronic pain.\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925 is being developed for the treatment of chronic pain conditions, including painful diabetic peripheral neuropathy and fibromyalgia. In this first\u2010in\u2010human, phase I, single\u2010ascending dose (50\u20131,200\u00a0mg) and multiple\u2010ascending dose (150\u2013900\u00a0mg) study, the safety, tolerability, and pharmacokinetics (PKs) of\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925 were evaluated in 84 healthy adult volunteers. No safety concerns emerged, including no dissociative side effects.\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925 exhibited dose\u2010proportional PKs and minimal accumulation following once\u2010daily dosing for 7\u00a0days. Cerebrospinal fluid (\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    ) measurements confirmed that\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925 crosses the blood brain barrier, with maximum\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    concentrations approximating 6\u20139% of maximum plasma concentrations at the same dose level.\n                    <jats:styled-content style=\"fixed-case\">NYX<\/jats:styled-content>\n                    \u20102925 was safe and well\u2010tolerated in healthy volunteers, and the study results support the continued clinical development for chronic pain conditions.\n                  <\/jats:p>","DOI":"10.1111\/cts.12584","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T09:16:50Z","timestamp":1537607810000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>NYX<\/scp>\n                    \u20102925, A Novel N\u2010methyl\u2010D\u2010aspartate Receptor Modulator: A First\u2010in\u2010Human, Randomized, Double\u2010blind Study of Safety and Pharmacokinetics in Adults"],"prefix":"10.1111","volume":"12","author":[{"given":"David R.","family":"Houck","sequence":"first","affiliation":[{"name":"Aptinyx Inc.  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