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Included were 1,693,658 infants divided into a training or testing subset in a ratio of 3:1. Forty\u2010two metabolites were analyzed using logistic regression (odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s), area under the receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>), 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s)). Several metabolite patterns remained consistent across gestational age groups for hyperbilirubinemia without kernicterus. Thyroid stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) and C\u201018:2 were decreased, whereas tyrosine and C\u20103 were increased in infants across groupings. Increased C\u20103 was also observed for kernicterus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.17; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.18\u20138.53). Thirty\u2010one metabolites were associated with hyperbilirubinemia without kernicterus in the training set. Phenylalanine (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.91; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.85\u20131.97), ornithine (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.76; 95% 0.74\u20130.77), and isoleucine\u00a0+\u00a0leucine (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.63; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.61\u20130.65) were the most strongly associated. This study showed that newborn metabolic function is associated with hyperbilirubinemia with and without kernicterus.<\/jats:p>","DOI":"10.1111\/cts.12590","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T15:24:22Z","timestamp":1540740262000},"page":"28-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus"],"prefix":"10.1111","volume":"12","author":[{"given":"Molly E.","family":"McCarthy","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Global Health Sciences and the Preterm Birth Initiative University of California San Francisco  San Francisco California USA"},{"name":"Department of Public Health Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott P.","family":"Oltman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and the California Preterm Birth Initiative University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Baer","sequence":"additional","affiliation":[{"name":"California Preterm Birth Initiative University of California San Francisco  San Francisco California USA"},{"name":"Department of Pediatrics University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli K.","family":"Ryckman","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Pediatrics University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth E.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the California Preterm Birth Initiative University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina A.","family":"Steurer\u2010Muller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Pediatrics and the California Preterm Birth Initiative University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Witte","sequence":"additional","affiliation":[{"name":"Institute for Human Genetics University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Jelliffe\u2010Pawlowski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and the California Preterm Birth Initiative University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12401"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31822c9b4c"},{"key":"e_1_2_9_3_1","first-page":"873","article-title":"Evaluation and treatment of neonatal hyperbilirubinemia","volume":"89","author":"Muchowski K.E.","year":"2014","journal-title":"Am. 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